The mesenchymal signature of high-grade gliomas is controlled by six transcription factors. TFs involved in activation of MGES targets are shown in pink, those involved in repression are in purple.
High-grade gliomas, such as glioblastoma, are incurable partly because the tumor cells are widely disseminated throughout the brain. This capacity for invasive growth has been associated with the expression of genes more commonly transcribed in mesenchymal cells. In work published in the journal Nature, Antonio Iavarone, Andrea Califano, and colleagues have identified a small transcription factor network that is responsible for the mesenchymal behavior of glioma cells.