Barry Honig

Barry Honig


Director, Center for Computational Biology and Bioinformatics
Professor, Department of Biochemistry and Molecular Biophysics
Investigator, Howard Hughes Medical Institute


Department of Systems Biology
Center for Computational Biology and Bioinformatics
Center for Cancer Systems Therapeutics
Department of Biochemistry and Molecular Biophysics
Department of Medical Sciences in Medicine
Zuckerman Mind Brain and Behavior Institute
Howard Hughes Medical Institute


(212) 851-4651

Administrative Assistant:
Katie Rosa

Barry Honig has been a professor of Biochemistry and Molecular Biophysics at Columbia University College of Physicians and Surgeons since 1981 and is director of the Center for Computational Biology and Bioinformatics (C2B2). He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and is a Howard Hughes Medical Institute (HHMI) Investigator. He is recipient of the Founders Award of the Biophysical Society, the Alexander Hollaender Award in Biophsyics from National Academy of Sciences, Christian B. Anfinsen Award from the Protein Society, and DeLano Award for Computational Biosciences from the American Society for Biochemistry and Molecular Biology. He has also been named a Fellow of the American Association for the Advancement of Science, the Biophysical Society, and the International Society for Computational Biology.

The guiding hypothesis of Dr. Honig’s work is that combining information about protein sequence with biophysical analysis can reveal how biological specificity is encoded on protein structures. His laboratory uses methods from biophysics and bioinformatics to study the structure and function of proteins, nucleic acids, and membranes. His work includes fundamental theoretical research, the development of software tools, and applications to problems of biological importance.

More News


Database of Protein-Protein Interactions Opens New Possibilities for Systems Biology
PrePPI uses protein structural data to predict the likelihood that any two proteins interact. Its unprecedented scope is enabling the Honig Lab to ask new kinds of biological questions.
Columbia Awarded NCI Center for Cancer Systems Biology
The Center for Cancer Systems Therapeutics (CaST) is developing a framework that can account for the dynamic nature of cancer and use this knowledge to disrupt the programs that maintain tumor survival.
Barry Honig Named ISCB Fellow
The award recognizes Honig's "seminal contributions to protein structure prediction and molecular electrostatics, and his more recent work on protein function prediction, protein-DNA recognition, and cell-cell adhesion.”
The Rise of Systems Biology
"'Science is more than a body of knowledge, it's a way of thinking,' remarked Carl Sagan, and probably his words were never more powerfully relevant than for portraying one of the newest biomedical fields, systems biology."
Uniting Structural and Systems Biology
When MAGNet was founded in 2005, one of its goals was to integrate methods from structural biology and systems biology in order to predict molecular networks. With the publication of a new algorithm for predicting protein-protein interactions, this goal has now been realized.
Barry Honig Wins Protein Society's Christian B. Anfinsen Award
The award was given "in recognition for his contributions to improve understanding of the electrostatic properties of proteins and the development of DelPhi and GRASP, which are among the most widely used programs in structural biology."
Barry Honig Wins DeLano Award for Computational Biosciences
The award is given to a scientist for innovative and accessible development or application of computer technology to enhance research in the life sciences at the molecular level.
Structural Nuance in the Double Helix and its Biological Role
In two recent papers in Cell and Nature, Barry Honig, Richard Mann, and colleagues have shown that sequence-dependent variations in the helix shape allow DNA-binding proteins to recognize their specific binding sites.
Barry Honig Inducted into the American Academy of Arts and Sciences
The Academy is an independent research center conducting multidisciplinary studies of problems in a wide range of fields.