Chaolin Zhang

Chaolin Zhang


Assistant Professor, Department of Systems Biology


Department of Systems Biology
Center for Computational Biology and Bioinformatics
Center for Motor Neuron Biology and Disease
Department of Biochemistry and Molecular Biophysics


(212) 305-9354

Chaolin Zhang uses a combination of computational and experimental methods to infer RNA regulatory networks in the nervous system. In particular, he is interested in characterizing the regulatory networks that specify neuronal cell types, and how how these networks can be compromised in certain pathologic contexts, such as brain tumors and neurodegenerative diseases.

After completing his PhD training at Cold Spring Harbor Laboratory and the Department of Biomedical Engineering at Stony Brook University, he was a member of Robert Darnell’s laboratory at the Rockefeller University, initially as a postdoctoral associate and later as a research assistant professor. While there, he studied neuron-specific RNA regulatory networks by developing an integrative modeling approach that combines multiple types of high-throughput data, including transcriptome profiles and protein-RNA interaction maps. He joined the Columbia Initiative in Systems Biology in 2012.

More News


DAMAGES: A Method for Predicting Rare Disease Risk Genes
Looking for distinctive gene expression patterns in different brain cell types offers a more efficient way to search for genetic alterations implicated in autism and reveals a molecular signature of the disorder.
Graduate Course Focuses on Foundations of Deep Sequencing
The new team-taught course provides an understanding of both the experimental principles of next-generation sequencing technologies and key statistical methods for analyzing the data they produce.