Harmen Bussemaker

Harmen Bussemaker


Professor, Department of Biological Sciences


Department of Biological Sciences
Department of Systems Biology
Center for Computational Biology and Bioinformatics


Work: (212) 854-1527

Harmen Bussemaker is an associate professor in the Department of Biological Sciences. His credentials include a Lenfest Distinguished Columbia Faculty Award and a John Simon Guggenheim Foundation Fellowship. Dr. Bussemaker is known for his pioneering efforts to understand gene regulatory networks by integrating information about genome sequence, transcription factor binding, and gene expression data. Using high-throughput sequencing and affinity-based selection, the Bussemaker lab aims to quantify the DNA binding specificity of transcription factors at unprecedented resolution. He is also using biophysical models to infer cell-state specific changes in the regulatory activity of transcription factors from genomewide mRNA expression levels. Other efforts include using natural genetic variation to dissect complex cis-regulatory logic, and understanding how local chromatin context modulates the influence of transcription factors on its target genes.

More News


New Method for Identifying Genetic Alterations that Modulate Gene Expression
The Bussemaker Lab showed that variants in cofactor genes called cQTLs can change the connectivity between transcription factors and their target genes.
Four Columbia Systems Biology Papers Named among Top Publications
The ISCB/RECOMB Conference on Regulatory and Systems Genomics has announced its top 10 papers of 2014-2015. Four of them involve investigators from the Columbia University Department of Systems Biology.
Harmen Bussemaker Named Guggenheim Fellow
The award supports a project that will combine methods from biophysics and genetics in order to predict the behavior of gene regulatory networks, and test these predictions using wet lab experiments.
Harmen Bussemaker Receives Lenfest Distinguished Columbia Faculty Award
The awards are given annually to faculty of unusual merit across a range of professorial activities, with a primary emphasis on the instruction and mentoring of undergraduate and graduate students.