Assistant Professor, Department of Systems Biology
Sagi Shapira was recruited to Columbia in 2011 as an assistant professor in the Columbia Initiative in Systems Biology and the Department of Microbiology and Immunology. His laboratory is working to decipher the genetic and molecular circuitry at the interface of host–pathogen interactions. His laboratory studies how this circuitry controls cellular responses to infection, imparts selective pressure on viruses, and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, he seeks to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host–pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and has broad implications in human translational immunology and infectious disease research.