Sagi Shapira

Sagi Shapira

Titles

Assistant Professor, Department of Systems Biology

Affiliations

Department of Systems Biology
Department of Microbiology and Immunology

Phone

(212) 305-5798

Sagi Shapira was recruited to Columbia in 2011 as an assistant professor in the Columbia Initiative in Systems Biology and the Department of Microbiology and Immunology. His laboratory is working to decipher the genetic and molecular circuitry at the interface of host–pathogen interactions. His laboratory studies how this circuitry controls cellular responses to infection, imparts selective pressure on viruses, and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, he seeks to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host–pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and has broad implications in human translational immunology and infectious disease research.


Education History


Selected Publications

Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell. 2011 Aug 19;146(4):633-44.

Shapira SD, Hacohen N. Systems biology approaches to dissect mammalian innate immunity. Curr Opin Immunol. 2011 Feb;23(1):71-7.

Shapira SD, Gat-Viks I, Shum BO, Dricot A, de Grace MM, Wu L, Gupta PB, Hao T, Silver SJ, Root DE, Hill DE, Regev A, Hacohen N. A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell. 2009 Dec 24;139(7):1255-67.


Address

Mailing Address:
Columbia University Department of Systems Biology
Irving Cancer Research Center
1130 St. Nicholas Avenue
New York, NY 10032

Office Location: 
Irving Cancer Research Center, 813A


Lab Staff

Postdoctoral Scientists

Postdoctoral Scientists

Takayuki Abe

Postdoctoral Research Scientist

Postdoctoral Research Scientist

Postdoctoral Scientists

Lila Ghamsari

Postdoctoral Research Scientist

Postdoctoral Research Scientist

Postdoctoral Scientists

Beatriz Leitao

Postdoctoral Research Scientist

Postdoctoral Research Scientist

Graduate Students

Graduate Students

Ohad Balaga

Graduate Student

Graduate Student


News

Sagi Shapira Joins Columbia Initiative in Systems Biology
Dr. Shapira's research focuses on deciphering the genetic and molecular circuitry that is at the interface of host-pathogen interactions.