Each year, participants in the ISCB/RECOMB Conference on Regulatory and Systems Genomics select publications over the past year that they consider to have made the most significant contributions to the field. During the most recent conference, held in Philadelphia on November 15-18, 2015, the top 10 papers were announced. Among those selected were four involving Columbia University Department of Systems Biology investigators. 

• Zhou T, Shen N, Yang L, Abe N, Horton J, Mann RS, Bussemaker HJ, Gordân R, Rohs R. Quantitative modeling of transcription factor binding specificities using DNA shape. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4654-9.
• Abe N, Dror I, Yang L, Slattery M, Zhou T, Bussemaker HJ, Rohs R, Mann RS. Deconvolving the recognition of DNA shape from sequence. Cell. 2015 Apr 9;161(2):307-18.
• Woo JH, Shimoni Y, Yang WS, Subramaniam P, Iyer A, Nicoletti P, Rodríguez Martínez M, López G, Mattioli M, Realubit R, Karan C, Stockwell BR, Bansal M, Califano A.  Elucidating compound mechanism of action by network perturbation analysis. Cell. 2015 Jul 16;162(2):441-51.
  (Read more about this paper here.)
• Sanchez-Garcia F, Villagrasa P, Matsui J, Kotliar D, Castro V, Akavia UD, Chen BJ, Saucedo-Cuevas L, Rodriguez Barrueco R, Llobet-Navas D, Silva JM, Pe'er D. Integration of genomic data enables selective discovery of breast cancer drivers. Cell. 2014 Dec 4;159(6):1461-75.
  (Read more about this paper here.)

The full list of Top 10 papers for 2014-2015 can be found on the conference website.

The next ISCB/RECOMB Conference on Regulatory and Systems Genomics, with DREAM Challenges and Cytoscape Workshop, will take place on November 6-10, 2016 in Phoenix, Arizona. Click here for more information.