Associate Research Scientist and Head, Cellular Assays, High-Throughput Screening, Columbia Genome Center
Hai Li is an associate scientist and Head of Cellular Assays at the Columbia Genome Center's High-Throughput Screening Facility. Her current research focus is cell-based assay development — specifically, designing and optimizing custom cell-based assays for a wide range of cell types including neurons, cancer cells, stem cells, B-cells, and others for high-throughput screening. Prior to joining the High-Throughput Screening Facility, she has worked with Chris Henderson at Columbia's Motor Neuron Center on high-throughput screening and target identification of small molecules with activity in CNS regeneration. She has also worked at the Salk Institute for Biological Studies on molecular biology of plant response to hormones. Hai received her PhD in Plant Biology at the Ohio State University.
PhD, The Ohio State University
Bachelor's Degree, Fudan University, Shanghai, China
Sonabend AM, Carminucci AS, Amendolara B, Bansal M, Leung R, Lei L, Realubit R, Li H, Karan C, Yun J, Showers C, Rothcock R, O J, Califano A, Canoll P, Bruce JN. Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma. Neuro Oncol. 2014 Mar 16.
Chang KN, Zhong S, Weirauch MT, Hon G, Pelizzola M, Li H, Huang SS, Schmitz RJ, Urich MA, Kuo D, Nery JR, Qiao H, Yang A, Jamali A, Chen H, Ideker T, Ren B, Bar-Joseph Z, Hughes TR, Ecker JR. Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis. Elife. 2013 Jun 11;2:e00675.
Li H, Johnson P, Stepanova A, Alonso JM, Ecker JR. Convergence of signaling pathways in the control of differential cell growth in Arabidopsis. Dev Cell. 2004 Aug;7(2):193-204. (Journal Cover).
Wang KL*, Li H*, Ecker JR. Ethylene biosynthesis and signaling networks. Plant Cell. 2002;14 Suppl:S131-51.
Zheng ZL, Nafisi M, Tam A, Li H, Crowell DN, Chary SN, Schroeder JI, Shen J, Yang Z. Plasma membrane-associated ROP10 small GTPase is a specific negative regulator of abscisic acid responses in Arabidopsis. Plant Cell. 2002 Nov;14(11):2787-97.
Fu Y, Li H, Yang Z. The ROP2 GTPase controls the formation of cortical fine F-actin and the early phase of directional cell expansion during Arabidopsis organogenesis. Plant Cell. 2002 Apr;14(4):777-94.
Jones MA, Shen JJ, Fu Y, Li H, Yang Z, Grierson CS. The Arabidopsis Rop2 GTPase is a positive regulator of both root hair initiation and tip growth. Plant Cell. 2002 Apr;14(4):763-76.
Li H, Shen JJ, Zheng ZL, Lin Y, Yang Z. The Rop GTPase switch controls multiple developmental processes in Arabidopsis. Plant Physiol. 2001 Jun;126(2):670-84.
Wu G, Li H, Yang Z. Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop- specific GTPase stimulation. Plant Physiol. 2000 Dec;124(4):1625-36.
Li H, Yang Z. Rho GTPase and the actin cytoskeleton. In: Actin: A Dynamic framework for multiple plant cell functions. Dordrecht, the Netherlands: Kluwer Academic Press. 2000;301-322.
Li H, Lin Y, Heath RM, Zhu MX, Yang Z. Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Plant Cell. 1999 Sep;11(9):1731-42.
Li H, Wu G, Ware D, Davis KR, Yang Z. Arabidopsis Rho-related GTPases: differential gene expression in pollen and polar localization in fission yeast. Plant Physiol. 1998 Oct;118(2):407-17.
Li H, Su W. NMI Analysis of the water distribution in peanut root under osmotic stress. Science in China (Series B). 1995;25:1291-95.