Kerry Goodman

Overview

Kerry Goodman

Titles

Senior Experimental Scientist
Honig-Shapiro Lab

Phone
+1 212-851-5369
Email
kg2518@columbia.edu

Lab

Barry Honig

Kerry Goodman is a senior experimental scientist in the laboratory of Lawrence Shapiro and Barry Honig. Her current research focuses on determining the atomic structure and adhesive properties of neural cell adhesion molecules, in order to further understand their role in determining and maintaining neural architecture and circuitry. Prior to this she completed her PhD in the laboratory of Neil McDonald at Cancer Research UK’s London Research Institute, where she studied the structure and function of the receptor tyrosine kinase Ret and its ligands.   

Education History

PhD, University College London
Structural Biology

MSci, Cambridge University
Natural Sciences

Publications

*indicates equal author contributions

Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. γ-Protocadherin structural diversity and functional implications. Elife. 2016 Oct 26;5. pii: e20930.

Goodman KM, Yamagata M, Jin X, Mannepalli S, Katsamba PS, Ahlsén G, Sergeeva AP, Honig B, Sanes JR, Shapiro L. Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife. 2016 Sep 19;5. pii: e19058.

Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L. Structural basis of diverse homophilic recognition by clustered α- and β-protocadherins. Neuron. 2016 May 18;90(4):709-23.

Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B. Molecular logic of neuronal self-recognition through protocadherin domain interactions. Cell. 2015 Oct 22;163(3):629-42. 

Goodman KM*, Kjær S*, Beuron F*, Knowles PP, Nawrotek A, Burns EM, Purkiss AG, George R, Santoro M, Morris EP, McDonald NQ. RET recognition of GDNF-GFRa ligand by a composite binding site promotes membrane-proximal self-association. Cell Rep. 2014 Sep 25;8(6):1894-1904. 

Plaza-Menacho I, Barnouin K, Goodman K, Martínez-Torres RJ, Borg A, Murray-Rust J, Mouilleron S, Knowles P, McDonald NQ. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol Cell. 2014; 53(5):738-51.

Darios F, Wasser C, Shakirzyanova A, Giniatullin A, Goodman K, Munoz-Bravo JL, Raingo J, Jorgacevski J, Kreft M, Zorec R, Rosa JM, Gandia L, Gutiérrez LM, Binz T, Giniatullin R, Kavalali ET and Davletov B. Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. Neuron. 2009 Jun 11;62(5):683-94.