Alternative 3' Untranslated Regions: Localization, Stability and Regulation
The Burge Lab studies mechanisms of posttranscriptional gene regulation using a combination of computational and experimental methods. One long-term goal of their work is to understand the RNA splicing code: how the precise locations of exons and splice sites are identified in primary transcripts, and how this code is altered in cell- and condition-specific alternative splicing. Their current efforts are focused on identifying splicing cis-regulatory elements and associated splicing factors, and understanding the context-dependent activities and functional interactions between these elements. They also study the roles that microRNAs (miRNAs) play in gene regulation, with an emphasis on determining the rules for miRNA-directed targeting of mRNAs. Other interests include the relationship between alternative cleavage and polyadenylation, which is commonly used to generate alternative mRNA isoforms differering in their 3' UTRs, and miRNA regulation. Learn more about the Burge Lab's work at http://genes.mit.edu/burgelab/.
The talk will include studies of myoblast and neuroblastoma cells, as well as primary neurons, emphasizing the role of the 3' UTR in determining localization to neurites (axons/dendrites).
Event Series Name
Add to Calendar 18-03-2015 16:00:00 18-03-2015 16:00:00 15 Christopher Burge (Massachusetts Institute of Technology) Department of Systems Biology Seminar Series Department of Systems Biology Common Room, ICRC 816 false MM/DD/YYYY