March 18, 2015 - 4:00pm

Alternative 3' Untranslated Regions: Localization, Stability and Regulation

Christopher Burge
Massachusetts Institute of Technology
Department of Systems Biology Common Room×


Irving Cancer Research Center
1130 St. Nicholas Avenue
Room 816
New York, NY 10032

The Burge Lab studies mechanisms of posttranscriptional gene regulation using a combination of computational and experimental methods. One long-term goal of their work is to understand the RNA splicing code: how the precise locations of exons and splice sites are identified in primary transcripts, and how this code is altered in cell- and condition-specific alternative splicing. Their current efforts are focused on identifying splicing cis-regulatory elements and associated splicing factors, and understanding the context-dependent activities and functional interactions between these elements.  They also study the roles that microRNAs (miRNAs) play in gene regulation, with an emphasis on determining the rules for miRNA-directed targeting of mRNAs. Other interests include the relationship between alternative cleavage and polyadenylation, which is commonly used to generate alternative mRNA isoforms differering in their 3' UTRs, and miRNA regulation. Learn more about the Burge Lab's work at

The talk will include studies of myoblast and neuroblastoma cells, as well as primary neurons, emphasizing the role of the 3' UTR in determining localization to neurites (axons/dendrites).

Event Series Name

Department of Systems Biology Seminar Series
Chaolin Zhang

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