Sagi Shapira

Sagi Shapira


Assistant Professor, Department of Systems Biology


Department of Systems Biology
Department of Microbiology and Immunology


(212) 305-2865

Sagi Shapira was recruited to Columbia in 2011 as an assistant professor in the Columbia Initiative in Systems Biology and the Department of Microbiology and Immunology. His laboratory is working to decipher the genetic and molecular circuitry at the interface of host–pathogen interactions. His laboratory studies how this circuitry controls cellular responses to infection, imparts selective pressure on viruses, and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, he seeks to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host–pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and has broad implications in human translational immunology and infectious disease research.

More News


Sex May Not Have Evolved Without Changes in Immune System
Sexual reproduction may have never become possible if organisms hadn’t evolved a way to restrain the immune system during fertilization, according to a new study from the lab of Sagi Shapira, PhD, assistant Professor of Systems Biology.
Department of Systems Biology Opens New Biotechnology Development Hub
The new space will promote the design of new experimental methods for studying biological systems, and enable an expansion of the Columbia Genome Center's next-generation sequencing capabilities.
Sagi Shapira Joins Columbia Initiative in Systems Biology
Dr. Shapira's research focuses on deciphering the genetic and molecular circuitry that is at the interface of host-pathogen interactions.