Julia de Vasconcellos Castro
Postdoctoral Research Scientist-Visiting Fellow
Castro's research interests combine her scientific and engineering training and expertise. Her work falls in a variety of general categories including chemical reaction engineering and biological/biomedical problems. Particular efforts have been done in order to understand fundamental aspects of gene structures and organization in bacterial biopolymer synthesis and hydrogen production, the role of transcription factors in regulating protein expression, and how secondary metabolite production may be optimized using metabolic engineering and other systems biology tools.
Julia is currently a Postdoctoral Research Fellow at teh Barry Honig's Laboratory of Molecular Biophysics, holding a position as a guest researcher at the Columbia University Center for Cancer Systems Therapeutics (CaST). She is part of a research group that aims to elucidate key tumor checkpoints and associated proteins across all individual tumor samples in TCGA and related sources to develop the Cancer Homeostasis Protein Database (CHoPD). More specifically, she is working with proteins predicted to be associated with the robust maintenance of Adenocarcinoma Lung Cancer and her goal is to analyze predicted protein binding regions in the disordered regions (or Molecular Recognition Feature - MoRFs) and related PDB structures. In addition, she is involved in cell and tissue engineering studies applied to cancer systems by using bacterial nanocellulose 3D scaffolds as a tumor growth platform and applying surface modifications as a strategy to control and guide interactions between cell and the hydrogel matrix.
PhD, Federal University of Santa Catarina, Brazil Chemical Engineering with a Biochemical Emphasis
BS, Federal University of Santa Catarina, Brazil Chemical Engineering with a Biochemical Emphasis
Castro, J.;Junior, A.F.,Porto, L.M.(2016). Monitoring changes in the Clostridium acetobutylicum ATCC 824 physiological state during batch process. Submitted for publication.
Souza, S.S., Castro, J. V.;Porto, L.M.(2016). Modeling the core metabolism in Gluconacetobacter hansenii ATCC 23769 to evaluate nanocellulose biosynthesis. Submitted for publication.