The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Meeting ReportInterdisciplinary Research Spotlighted at Inaugural Department of Systems Biology Symposium
The first public event held by the Department of Systems Biology highlighted ways in which approaches based in computational and systems biology are contributing to research at Columbia.
In the PressThe Rise of Systems Biology
"'Science is more than a body of knowledge, it's a way of thinking,' remarked Carl Sagan, and probably his words were never more powerfully relevant than for portraying one of the newest biomedical fields, systems biology."
Research NewsA Topological Approach to Modeling Evolution
Charles Darwin visualized the differentiation of species like the branches of a tree, but recent genomic studies suggest that this model is insufficient to describe evolution at the molecular level.
Research NewsBiomarker Identified for Predicting Prostate Cancer Aggressiveness
Measurements of the expression levels of three genes associated with aging can be used to better assess which patients with indolent prostate cancer require treatment.
Research NewsStudy Reveals Genes That Drive Glioblastoma
Using a new statistical method developed in the lab of Raul Rabadan, a Columbia University team identified 18 new genes responsible for this aggressive form of brain cancer. Some of these genes could be targeted with existing FDA-approved drugs.
AnnouncementAnnouncing the New Columbia University Department of Systems Biology
This step recognizes the growth in systems biology research and education that has taken place at Columbia, and formally establishes the discipline as a major research area for the university.
Research NewsNew Tool for Visualizing High-Dimensional Single-Cell Data
A new software tool called viSNE can reveal closely related groups of cells within heterogeneous cell populations. It could potentially help identify drug-resistant cancer cells and detect minute quantities of cells that increase risk of relapse.
Research NewsStudy of Cancer Metabolism Identifies Potential Drug Targets
A study led by Dennis Vitkup and postdoctoral research scientist Jie Hu has identified a broad spectrum of metabolic expression changes associated with cancer, as well as hundreds of possible targets for starving tumors.
Research NewsAnastassiou Lab Is a Best Performer in DREAM Breast Cancer Challenge
By looking for "attractor metagenes" in genomic and clinical data, a Columbia University team developed a computational model that was best able to predict prognosis.
AnnouncementHarris Wang Joins Columbia
Dr. Wang uses approaches from systems and synthetic biology to understand the principles behind the formation, maintenance, and evolution of genomes in microbial populations, with the goal of engineering ecologies of microbes in ways that could improve human health.
Research NewsWeb Search Logs Reveal Adverse Drug Interactions
Statistical analysis of Internet search data could offer a more efficient method for spotting early warning signs of dangerous drug reactions.
Meeting ReportHigh-Throughput Screening and Chemistry Symposium
Learn about the Columbia Genome Center's capabilities in high-throughput screening and synthetic chemistry, and some recent research at Columbia that utilized these tools.
ProfileAt the Vanguard of a Revolution in Computational Genetics
Itsik Pe'er uses mathematics and computer analytics to identify the genetic makeup of the founding Ashkenazi Jews.
Research NewsStudy Supports Cell-of-Origin Model of Prostate Cancer Heterogeneity
The cell-of-origin model suggests that the aggressiveness of a tumor may result from the type of cell from which it arises. A new study has identified molecular signatures that hold potential as biomarkers of specific prostate cancer subtypes.
Events and Seminars
December 4, 2013 - 1:00pm to 4:00pm
Andrea Califano, Chaolin Zhang, Charles LeDuc, Xiaojun Feng, Michael G. Smith
November 25, 2013 - 1:00pm
Cameron Palmer(Itsik Pe'er Lab)
November 21, 2013 - 4:00pm
Albert Lee (Rabadan Lab) and Nanfang Xu (Yufeng Shen Lab)
On crowd-verification of biological networks. Bioinform Biol Insights
Time-dependent information transmission in a model regulatory circuit. Phys Rev E Stat Nonlin Soft Matter Phys