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Meeting Report
Department of Systems Biology Annual Retreat Spotlights New Research
Nathan Johns and Antonio Gomes won the Distinguished Poster Award on a day that showcased a variety of new methods and discoveries emerging from Department laboratories.
Research News
Method for Analyzing Single-Cell Data Identifies AML Stem Cells
A new algorithm called PhenoGraph revealed a signaling-based signature of this elusive cell type and enabled scientists to define a gene expression signature that is predictive of leukemia patient survival.
Research News
Data Scientists Find Connections Between Birth Month and Health
Scientists led by assistant professor Nicholas Tatonetti have developed a computational method to investigate the relationship between birth month and disease risk, finding 55 diseases that correlated with season of birth.
Research News
Mechanism of Kidney Transplant Tolerance Discovered
A new statistical approach for tracking expansion of rare T cell clones developed in Yufeng Shen's lab could make it possible to predict transplant rejection and provide evidence to guide the use of immuno- suppressive drugs.
Awards and Grants
Columbia Investigators Awarded New NCI Physical Sciences in Oncology Center
The Center for Topology of Cancer Evolution and Heterogeneity will combine new mathematical approaches and single-cell experimental technologies to study cellular diversity in solid tumors.
Awards and Grants
Harris Wang Named Office of Naval Research Young Investigator
The project will focus on developing a new, targeted genome engineering approach, expanding the library of useful plasmid vectors, and exploring new DNA transformation methods in microbial communities.
Awards and Grants
Rodney Rothstein Elected to National Academy of Sciences
NAS members are chosen by their peers in recognition of their distinguished achievements. Dr. Rothstein is a pioneer in the use of recombination to study genes that help maintain genome stability.
Research News
Connections Found between Mendelian Diseases and Cancer
Using electronic health records representing over 110 million patients, investigators in the Rabadan Lab show that comorbidity of Mendelian diseases and cancer can be tied to genetic changes seen in both diseases.
The Exposome: Connecting Environmental Factors to Human Disease
Pollutants in the air, chemicals in food, and prescription drugs all affect health. Assistant Professor Nicholas Tatonetti is using large environmental and genetic data sets to explore how.
Research News
Rare, Deadly Lymphoma Demystified
The first systematic study of genomes of patients with ALK-negative anaplastic large cell lymphoma, an aggressive form of non-Hodgkin’s lymphoma, shows that many cases are driven by alterations in the JAK/STAT3 cell signaling pathway.
Research News
Functional Metagenomics Enables First Study of Bacterial Fitness in the Gut Microbiome
A new method called TFUMseq offers a relatively simple way to study the dynamics of the microbiome, and to engineer bacterial strains to thrive in the gut.
Research News
Tracing Bacterial Evolution Across Billions of Years
Using simulations of metabolism as a kind of microscope, Dennis Vitkup and Germán Plata have identified patterns in how bacteria adapt and diversify at the phenotypic level, an important issue in evolutionary biology.