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Interview
The Exposome: Connecting Environmental Factors to Human Disease
Pollutants in the air, chemicals in food, and prescription drugs all affect health. Assistant Professor Nicholas Tatonetti is using large environmental and genetic data sets to explore how.
Research News
Rare, Deadly Lymphoma Demystified
The first systematic study of genomes of patients with ALK-negative anaplastic large cell lymphoma, an aggressive form of non-Hodgkin’s lymphoma, shows that many cases are driven by alterations in the JAK/STAT3 cell signaling pathway.
Research News
Functional Metagenomics Enables First Study of Bacterial Fitness in the Gut Microbiome
A new method called TFUMseq offers a relatively simple way to study the dynamics of the microbiome, and to engineer bacterial strains to thrive in the gut.
Research News
Tracing Bacterial Evolution Across Billions of Years
Using simulations of metabolism as a kind of microscope, Dennis Vitkup and Germán Plata have identified patterns in how bacteria adapt and diversify at the phenotypic level, an important issue in evolutionary biology.
Awards and Grants
Columbia Researchers Will Use Master Regulators to Reclassify Cancer Subtypes
The project aims to provide a catalog of pan-cancer subtypes that could identify biomarkers and therapeutic targets for specific kinds of tumors, and guide the next generation of precision medicine.
Awards and Grants
Harris Wang Named Winner of Sloan Research Fellowship
This prestigious award for early-career scientists will support work that combines methods from synthetic biology and computational biology to study how horizontal gene transfer contributes to microbial evolution.
Research News
Diverse Autism Mutations Lead to Different Disease Outcomes
People with autism exhibit a wide range of symptoms. Now a large-scale analysis of hundreds of patients has started to uncover how diversity among traits can be traced to differences in patients’ genetic mutations.
Research News
Distinguishing Patterns of Tumor Evolution in Chronic Lymphocytic Leukemia
A new computational method developed in the laboratory of Raul Rabadan has made it possible to determine the order in which mutations occur in cancer, providing insights into disease progression.
Research News
Novel Machine Learning Method Expands the Landscape of Breast Cancer Driver Genes
An algorithm by recent PhD graduate Felix Sanchez-Garcia identifies cancer causing genes within somatic copy number alterations, doubling the number of known breast cancer drivers.
Research News
Algorithm Identifies Genetic Driver of Mesenchymal Glioblastoma
Combined with other tools developed in the Califano Lab, DIGGIT identified KLHL9 deletion as a cause of GBM. The algorithm offers a new method for identifying genetic drivers of disease.
Awards and Grants
Prestigious NIH Director's Awards Go to Two Department of Systems Biology Researchers
Associate Professor Dana Pe’er has received the Pioneer Award for high risk, high reward research, while postdoctoral scientist Kyle Allison has won an Early Independence Award.
Announcement
Three CUMC Faculty Members Receive Interdisciplinary Appointments
Columbia University Medical Center professors Oliver Hobert, Richard Mann, and Rodney Rothstein have joined the Department of Systems Biology to facilitate collaborative research.