The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Awards and GrantsColumbia Investigators Awarded New NCI Physical Sciences in Oncology Center
The Center for Topology of Cancer Evolution and Heterogeneity will combine new mathematical approaches and single-cell experimental technologies to study cellular diversity in solid tumors.
Awards and GrantsHarris Wang Named Office of Naval Research Young Investigator
The project will focus on developing a new, targeted genome engineering approach, expanding the library of useful plasmid vectors, and exploring new DNA transformation methods in microbial communities.
Awards and GrantsRodney Rothstein Elected to National Academy of Sciences
NAS members are chosen by their peers in recognition of their distinguished achievements. Dr. Rothstein is a pioneer in the use of recombination to study genes that help maintain genome stability.
Research NewsConnections Found between Mendelian Diseases and Cancer
Using electronic health records representing over 110 million patients, investigators in the Rabadan Lab show that comorbidity of Mendelian diseases and cancer can be tied to genetic changes seen in both diseases.
InterviewThe Exposome: Connecting Environmental Factors to Human Disease
Pollutants in the air, chemicals in food, and prescription drugs all affect health. Assistant Professor Nicholas Tatonetti is using large environmental and genetic data sets to explore how.
Research NewsRare, Deadly Lymphoma Demystified
The first systematic study of genomes of patients with ALK-negative anaplastic large cell lymphoma, an aggressive form of non-Hodgkin’s lymphoma, shows that many cases are driven by alterations in the JAK/STAT3 cell signaling pathway.
Research NewsFunctional Metagenomics Enables First Study of Bacterial Fitness in the Gut Microbiome
A new method called TFUMseq offers a relatively simple way to study the dynamics of the microbiome, and to engineer bacterial strains to thrive in the gut.
Research NewsTracing Bacterial Evolution Across Billions of Years
Using simulations of metabolism as a kind of microscope, Dennis Vitkup and Germán Plata have identified patterns in how bacteria adapt and diversify at the phenotypic level, an important issue in evolutionary biology.
Awards and GrantsColumbia Researchers Will Use Master Regulators to Reclassify Cancer Subtypes
The project aims to provide a catalog of pan-cancer subtypes that could identify biomarkers and therapeutic targets for specific kinds of tumors, and guide the next generation of precision medicine.
Research NewsDiverse Autism Mutations Lead to Different Disease Outcomes
People with autism exhibit a wide range of symptoms. Now a large-scale analysis of hundreds of patients has started to uncover how diversity among traits can be traced to differences in patients’ genetic mutations.
Research NewsDistinguishing Patterns of Tumor Evolution in Chronic Lymphocytic Leukemia
A new computational method developed in the laboratory of Raul Rabadan has made it possible to determine the order in which mutations occur in cancer, providing insights into disease progression.
Research NewsNovel Machine Learning Method Expands the Landscape of Breast Cancer Driver Genes
An algorithm by recent PhD graduate Felix Sanchez-Garcia identifies cancer causing genes within somatic copy number alterations, doubling the number of known breast cancer drivers.
Events and Seminars
June 5, 2015 - 8:30am to 5:30pm
Department of Systems Biology Members
June 10, 2015 - 3:00pm
Yaniv Erlich(Department of Computer Science)
June 15, 2015 - 4:00pm
[Please note change of date]
Detection of Minimal Residual Disease in B Lymphoblastic Leukemia Using viSNE. Cytometry B Clin Cytom