The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Research NewsNovel Machine Learning Method Expands the Landscape of Breast Cancer Driver Genes
An algorithm by recent PhD graduate Felix Sanchez-Garcia identifies cancer causing genes within somatic copy number alterations, doubling the number of known breast cancer drivers.
Research NewsImproving Single-Cell RNA-Seq at the Columbia Genome Center
Using the Fluidigm C1 System, Columbia researchers are developing methods for addressing the technical challenges of single-cell sequencing, and have begun generating some exciting data.
Upcoming EventsDepartment of Systems Biology Announces 2014-2015 Seminar Series
This year's visiting speakers series will include William Hahn, Nancy Cox, Stephen Quake, Frank McCormick, and others. Click on the link above for the complete schedule, and mark your calendars!
Research NewsAlgorithm Identifies Genetic Driver of Mesenchymal Glioblastoma
Combined with other tools developed in the Califano Lab, DIGGIT identified KLHL9 deletion as a cause of GBM. The algorithm offers a new method for identifying genetic drivers of disease.
Awards and GrantsPrestigious NIH Director's Awards Go to Two Department of Systems Biology Researchers
Associate Professor Dana Pe’er has received the Pioneer Award for high risk, high reward research, while postdoctoral scientist Kyle Allison has won an Early Independence Award.
AnnouncementThree CUMC Faculty Members Receive Interdisciplinary Appointments
Columbia University Medical Center professors Oliver Hobert, Richard Mann, and Rodney Rothstein have joined the Department of Systems Biology to facilitate collaborative research.
InterviewNew Directions in Genome Engineering: An Interview with Harris Wang
Dr. Wang describes (MO)-MAGE, a new technology he developed for mutating large numbers of genes in a targeted way, and the exciting opportunities it offers for the field of synthetic biology.
Research NewsStudy Sheds Light on Ashkenazi Jewish Genome and Ancestry
Findings from an international consortium led by Itsik Pe'er provide evidence of a population bottleneck in medieval Europe and could enable improvements in personalized medicine for this isolated population.
EducationGraduate Students Awarded Training Grants
Congratulations to Albert Lee and Chaitanya Rastogi, who have been named awardees of these competitive fellowships, which provide support for outstanding students working toward a PhD in Department of Systems Biology laboratories.
AnnouncementColumbia Genome Center Now Offers NextSeq 500 Self-Service
Columbia investigators who are experienced with the Illumina platform can now schedule time to use this advanced, efficient technology for exome, transcriptome, and small genome sequencing.
Research NewsProtein Found that Promotes Breast Cancer Metastasis
Saeed Tavazoie and researchers at Rockefeller University have discovered that the RNA binding protein TARBP2 drives metastasis and identified tantalizing connections between cancer and two neurodegenerative diseases.
AnnouncementMAGNet Releases Web Browser-Enabled Version of geWorkbench Bioinformatics Software Platform
An upgrade of MAGNet's software platform makes it easier to access an integrated collection of computational tools for research in structural and systems biology.
Events and Seminars
January 6, 2015 - 3:00pm
Jay Shendure(University of Washington)
January 21, 2015 - 4:00pm
William Hahn(Dana-Farber Cancer Institute)
Predicting protein networks in cancer. Nat Genet