The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Awards and GrantsHarris Wang Named Recipient of Presidential Early Career Award
The PECASE is considered the United States’ highest award for early career scientists and engineers, recognizing exceptional innovation and leadership at the frontiers of knowledge and technology development.
Awards and GrantsColumbia Scientists Receive Grant to Integrate Clinical and Molecular Data
Medical doctors and basic scientists tend to speak about human health in different languages. A project called DeepLink aims to provide a way to translate knowledge across multiple scales.
Research NewsCancer Oncotecture: A Universal Model of Tumor Survival
A Perspective article in Nature Reviews Cancer argues that targeting the proteins that direct a cancer cell’s behavior instead of the genetic alterations that initially turn it malignant could offer an effective way to classify and treat disease.
InterviewA Grand Challenge for Genome Engineering: GP-write
In June 2016 an international consortium announced an ambitious proposal to develop new technologies for synthesizing large genomes. Virginia Cornish and Harris Wang discuss what the effort hopes to achieve.
Research NewsDatabase of Protein-Protein Interactions Opens New Possibilities for Systems Biology
PrePPI uses protein structural data to predict the likelihood that any two proteins interact. Its unprecedented scope is enabling the Honig Lab to ask new kinds of biological questions.
Research NewsDAMAGES: A Method for Predicting Rare Disease Risk Genes
Looking for distinctive gene expression patterns in different brain cell types offers a more efficient way to search for genetic alterations implicated in autism and reveals a molecular signature of the disorder.
EducationColumbia Systems Biology Launches Master's Course with School of Professional Studies
The course is designed for anyone interested in understanding how systems biology is helping to address today’s grand challenges in biomedical research.
Research NewsAutomated, Single Cell RNA-Seq Enables Research on Tumor Ecology
A new technology developed in the Sims Lab makes it easier to explore functional diversity among cancer cells, and is playing a key role in several Department research projects.
Upcoming Events2016-2017 Seminar Series Announced
Mark your calendars for these upcoming events! Invited speakers will discuss a range of topics topics in computational biology, epigenomics, evolutionary biology, gene regulation, cancer systems biology, and developmental biology, among others.
InterviewA Jack of All Trades: An Interview with Kam Leong
The biomedical engineer explains how nanotechnologies he has developed could support systems biology research and why interdisciplinary collaboration is so important to science and engineering today.
EducationYoung Investigators Celebrated at Annual Department Retreat
Winners of the Best Poster Competition focused on topics including human genetics, the molecular basis of neuron self-recognition, glioblasoma tumor evolution, and new technologies for single-cell RNA-seq analysis.
In the PressCan Math Crack Cancer's Code?
An essay coauthored by Department of Systems Biology Chair Andrea Califano in the Wall Street Journal asks whether quantitative modelling could hold the keys to identifying proteins that function as on/off switches for cancer.
Events and Seminars
January 30, 2017 - 5:00pm
February 1, 2017 - 3:00pm▶ More information
February 13, 2017 - 5:00pm