The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
AnnouncementColumbia Genome Center Now Offers NextSeq 500 and MiSeq Self-Service
Columbia investigators who are experienced with the Illumina platform can now schedule time to use these advanced technologies for exome, transcriptome, and small genome sequencing.
Research NewsProtein Found that Promotes Breast Cancer Metastasis
Saeed Tavazoie and researchers at Rockefeller University have discovered that the RNA binding protein TARBP2 drives metastasis and identified tantalizing connections between cancer and two neurodegenerative diseases.
AnnouncementMAGNet Releases Web Browser-Enabled Version of geWorkbench Bioinformatics Software Platform
An upgrade of MAGNet's software platform makes it easier to access an integrated collection of computational tools for research in structural and systems biology.
In the PressColumbia Launches Initiative to Advance Personalized Medicine
The Spring 2014 issue of Columbia Medicine reports on a university-wide project to identify more patient-specific ways to diagnose and treat disease, and the key role the Department of Systems Biology is playing in this effort.
Meeting ReportDepartment of Systems Biology Holds Annual MAGNet Retreat
Postdoctoral research scientist Sayantan Bose received a best poster award at a meeting that also provided an overview of the diverse computational and experimental research currently underway around the Department.
Research NewsSynergy between Two Genes Drives Aggressive Prostate Cancer
Using a new computational method for comparing regulatory networks in human cancer cells with those in a mouse model, researchers found that FOXM1 and CENPF together drive the most lethal prostate tumors.
AnnouncementMolly Przeworski Named Professor at Columbia
A specialist in evolutionary genetics, Dr. Przeworski combines modeling, development of statistical tools, and data analysis to study how natural selection and recombination shape the heritable differences seen among individuals and species.
Research NewsResearchers Create Comprehensive Map of Human B Cell Development
A method that uses new single-cell technologies will improve researchers’ ability to investigate development in cells of all types and to identify rare aberrations in development that lead to disease.
Awards and GrantsGrant Will Support Annotation of Metabolic Networks in Pathogenic Bacteria
A team led by Associate Professor Dennis Vitkup has received a multiyear grant to develop models of metabolic networks for all of the major bacterial species that cause disease in humans.
Awards and GrantsBrent Stockwell Receives 2014 Lenfest Distinguished Teaching Award
The Lenfest Award recognizes Columbia University faculty who are both accomplished scholars and provide exceptional instruction, mentorship, and leadership.
In the PressWhy the New York Times Hired a Biology Researcher as Its Chief Data Scientist
Fast Company magazine speaks with Department of Systems Biology Associate Professor Chris Wiggins about the shared challenges that the natural sciences and the media are both facing in the age of big data.
InterviewOn Being Thrown Out of the Box: An Interview with Saeed Tavazoie
Dr. Tavazoie discusses his research in the areas of gene transcription, post-transcriptional regulation, and molecular evolution, and how novel technologies coming out of systems biology push scientists to think in new ways.
AnnouncementPeter Sims Appointed to Columbia Genome Center
As Associate Director for Novel Technologies, Dr. Sims will devise, direct, and implement strategies for incorporating new high-throughput experimental methods into the research done at the Genome Center.
Awards and GrantsDana Pe’er Wins 2014 Overton Prize
The award from the International Society for Computational Biology recognizes one outstanding early- to mid-career scientist each year who has already made a significant contribution to the field.
AnnouncementTuuli Lappalainen Joins Department of Systems Biology
Dr. Lappalainen is a specialist in the analysis of RNA sequencing data, with research interests including functional variation in the human genome, the population genetics of genomic variation, and the interpretation of genome function.
Events and Seminars
Analyses of tumor-suppressor genes in germline mouse models of cancer. Cold Spring Harb Protoc