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In the Press
Can Math Crack Cancer's Code?
An essay coauthored by Department of Systems Biology Chair Andrea Califano in the Wall Street Journal asks whether quantitative modelling could hold the keys to identifying proteins that function as on/off switches for cancer.
Research News
Scientists Quantify Genetic Connections between Cancer and Developmental Disorders
A study led by Yufeng Shen suggests that cancer data could be used to pinpoint rare, damaging genetic alterations that increase the risk of developmental syndromes like autism.
Awards and Grants
Columbia Awarded NCI Center for Cancer Systems Biology
The Center for Cancer Systems Therapeutics (CaST) is developing a framework that can account for the dynamic nature of cancer and use this knowledge to disrupt the programs that maintain tumor survival.
Research News
Method for Determining Protein Function Opens Opportunities for Precision Cancer Medicine
A new algorithm called VIPER offers the first method for analyzing a single tumor biopsy to identify proteins that drive cancerous activity in individual patients.
Research News
Study of Glioblastoma Tumor Evolution Reveals Strategies Against Advanced Disease
Genetically distinct populations of cells appear to drive malignancy before and after therapy. The findings provide insights into GBM drug resistance and how it might be overcome.
Research News
Graduate Students Invent Technique for Reprogramming Translation
MD/PhD students Andrew Anzalone and Sakellarios Zairis engineered RNA motifs capable of inducing ribosomal frameshifting. Their method could offer new opportunities for synthetic biology.
Research News
New Method for Identifying Genetic Alterations that Modulate Gene Expression
The Bussemaker Lab showed that variants in cofactor genes called cQTLs can change the connectivity between transcription factors and their target genes.
Education
Systems Biology Scientists Help Expand Microbiome Research
A cross-departmental Microbiome Working Group is building bridges between computational biologists and other CUMC investigators interested in understanding how the human microbiome affects health.
Awards and Grants
Barry Honig Named ISCB Fellow
The award recognizes Honig's "seminal contributions to protein structure prediction and molecular electrostatics, and his more recent work on protein function prediction, protein-DNA recognition, and cell-cell adhesion.”
Research News
Tatonetti Lab Connects Drug Interactions to Deadly Heart Condition
Using a new data science method for analyzing observational data and validating predictions, the scientists identified several drug combinations that appear to cause a dangerous type of arrhythmia called torsades de pointes.
Education
New Course Covers Fundamentals of High-Performance Computing
Developed by the Mailman School of Public Health in partnership with the Department of Systems Biology, it addresses practical and theoretical challenges facing scientists interested in analyzing large data sets.
In the Press
Wang Lab Work on Bioeconomics Featured in Wall Street Journal
A collaboration between a biologist and an economist led to a new framework for describing how bacteria exchange metabolic resources. It offers a new lens for studying microbial communities based on economic theories.