The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Research NewsDiverse Autism Mutations Lead to Different Disease Outcomes
People with autism exhibit a wide range of symptoms. Now a large-scale analysis of hundreds of patients has started to uncover how diversity among traits can be traced to differences in patients’ genetic mutations.
Research NewsDistinguishing Patterns of Tumor Evolution in Chronic Lymphocytic Leukemia
A new computational method developed in the laboratory of Raul Rabadan has made it possible to determine the order in which mutations occur in cancer, providing insights into disease progression.
Research NewsNovel Machine Learning Method Expands the Landscape of Breast Cancer Driver Genes
An algorithm by recent PhD graduate Felix Sanchez-Garcia identifies cancer causing genes within somatic copy number alterations, doubling the number of known breast cancer drivers.
Upcoming EventsDepartment of Systems Biology Announces 2014-2015 Seminar Series
This year's visiting speakers series will include William Hahn, Nancy Cox, Stephen Quake, Frank McCormick, and others. Click on the link above for the complete schedule, and mark your calendars!
Research NewsAlgorithm Identifies Genetic Driver of Mesenchymal Glioblastoma
Combined with other tools developed in the Califano Lab, DIGGIT identified KLHL9 deletion as a cause of GBM. The algorithm offers a new method for identifying genetic drivers of disease.
Awards and GrantsPrestigious NIH Director's Awards Go to Two Department of Systems Biology Researchers
Associate Professor Dana Pe’er has received the Pioneer Award for high risk, high reward research, while postdoctoral scientist Kyle Allison has won an Early Independence Award.
AnnouncementThree CUMC Faculty Members Receive Interdisciplinary Appointments
Columbia University Medical Center professors Oliver Hobert, Richard Mann, and Rodney Rothstein have joined the Department of Systems Biology to facilitate collaborative research.
InterviewNew Directions in Genome Engineering: An Interview with Harris Wang
Dr. Wang describes (MO)-MAGE, a new technology he developed for mutating large numbers of genes in a targeted way, and the exciting opportunities it offers for the field of synthetic biology.
Research NewsStudy Sheds Light on Ashkenazi Jewish Genome and Ancestry
Findings from an international consortium led by Itsik Pe'er provide evidence of a population bottleneck in medieval Europe and could enable improvements in personalized medicine for this isolated population.
EducationGraduate Students Awarded Training Grants
Congratulations to Albert Lee and Chaitanya Rastogi, who have been named awardees of these competitive fellowships, which provide support for outstanding students working toward a PhD in Department of Systems Biology laboratories.
Research NewsProtein Found that Promotes Breast Cancer Metastasis
Saeed Tavazoie and researchers at Rockefeller University have discovered that the RNA binding protein TARBP2 drives metastasis and identified tantalizing connections between cancer and two neurodegenerative diseases.
AnnouncementMAGNet Releases Web Browser-Enabled Version of geWorkbench Bioinformatics Software Platform
An upgrade of MAGNet's software platform makes it easier to access an integrated collection of computational tools for research in structural and systems biology.
Events and Seminars
February 4, 2015 - 3:00pm▶ More information
March 4, 2015 - 3:00pm▶ More information
March 18, 2015 - 4:00pm▶ More information
Predicting protein networks in cancer. Nat Genet