Because systems biology and computational biology are by their natures multidisciplinary, many Department of Systems Biology faculty members who participate in our graduate programs also have cross-appointments in other departments. Students can apply through the Integrated Program in Cellular, Molecular, and Biomedical Studies or apply directly to other departments in which our faculty members hold their primary appointments.

The following list includes programs, departments, and faculty with relationships to the Columbia Department of Systems Biology.

Integrated Program in Cellular, Molecular, and Biomedical Studies

The Integrated Program is an interdepartmental program at Columbia University Medical Center that offers PhD education across a wide range of disciplines. The Department of Systems Biology and Center for Computational Biology and Bioinformatics have created a special track within the Integrated Program, enabling graduate students to work with any member of the Department of Systems Biology faculty as a mentor. 

Department of Applied Physics and Applied Mathematics

The Department of Applied Physics and Applied Mathematics applies mathematical and physical methods to diverse areas, including the modeling of biological systems.

  • Chris Wiggins - Machine learning applications for the study of biological problems; stochastic modeling of transcriptional regulatory networks.

Department of Biochemistry and Molecular Biophysics

The Department of Biochemistry and Molecular Biophysics offers training in diverse areas including structural biology, molecular and cell biology, biophysics, and neurobiology.

Department of Biomedical Informatics

The Department of Biomedical Informatics is particularly suited to students interested in approaching systems biology from an informatics perspective, particularly by integrating biological data, electronic health records, and other information.

  • Andrea Califano - Computational and experimental characterization of gene regulatory networks, systems chemical biology
  • Aris Floratos - Computational biology, bioinformatics software development, algorithmic methods for pattern and association discovery in genomic data
  • Raul Rabadan - Viral evolution, cancer mechanisms, and inference from medical records
  • Yufeng Shen - Statistical genomics and personalized medicine
  • Nicholas Tatonetti - Integration of heterogeneous data types.
  • Dennis Vitkup - Biological pathways and inheritance of complex traits

Department of Biological Sciences

The Department of Biological Sciences offers broad training in biology.

  • Harmen Bussemaker - Modeling the regulation of gene expression and chromatin structure based on microarray data and complete genomes.
  • Molly Przeworski - Effects of natural selection on genetic variation.

Department of Chemistry

Faculty in the Department of Chemistry conduct research at the intersection of chemical biology and systems biology, developing methods for synthesizing novel chemicals and studying the role of small molecules within cellular regulatory networks.

  • Virginia Cornish - Engineering of artificial pathways in cells to test biological networks and develop new technologies for treating disease.
  • Brent Stockwell - Synthesis of novel small organic molecules for perturbing cellular processes.

Department of Computer Science

The Department of Computer Science provides education in the theory and practice of computation, including approaches to computational biology that use an algorithmic or machine-learning perspective.

  • Itsik Pe'er - Computational methods to analyze SNP and resequencing data in human genetics.

Department of Electrical Engineering

The Department of Electrical Engineering offers broad training in the design of electronic and computational devices, including specialized processors for biological computation.

Department of Genetics & Development

The Department of Genetics and Development provides a broad range of training in genetics and animal development through the Graduate Program in Basic Cell and Molecular Biology.

  • Michael Shen - Mammalian embryogenesis and stem cell differentiation, and prostate development and carcinogenesis

Department of Microbiology & Immunology

The Department of Microbiology and Immunology combines modern molecular biology with research on infectious disease and immunology.

  • Sagi Shapira - Genetic and molecular networks involved in host-pathogen interactions.

Department of Pathology and Cell Biology

The Department of Cell Biology has concentrations in neurodegenerative diseases, stem cell biology, and cancer biology.

  • Harris Wang - Synthetic biology approaches for engineering microbial populations, including the gut microbiome.