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New Method Detects Genetic Expression Disruptors, Improves Diagnosis of Rare Disease
In a new study published in Science, researchers from New York Genome Center and Columbia University demonstrate a new method for analyzing genomes to better identify all mutations that disrupt gene function. The study was led by Pejman Mohammadi, PhD, a former postdoctoral scientist at the New York Genome Center and Columbia, and supervised by Tuuli Lappalainen, PhD, core faculty member at the New York Genome Center and an assistant professor of systems biology.
Research News
Personalized Gene Delivery to the Gut
A team of researchers, led by Dr. Harris Wang, has engineered bacteria to benefit and improve the overall health of our gut microbiome. In a proof-of-concept paper published in Nature Methods, the researchers demonstrate MAGIC, a gene delivery system that ‘hacks’ the gut microbiome to perform any desired genetic function, from harvesting energy from food and protecting against pathogen invasion to bolstering anti-inflammatory properties and regulating immune responses.
Research News
Biological ‘Rosetta Stone’ Brings Scientists Closer to Deciphering How the Body is Built
An international research team co-led by Richard Mann, PhD, from the Department of Systems Biology, have discovered a method that can systematically identify the role each Hox gene plays in a developing fruit fly. Their results, reported recently in Nature Communications, offer a new path forward for researchers hoping to make sense of a process that is equal parts chaotic and precise, and that is critical to understanding not only growth and development but also aging and disease.
Awards and Grants
Dr. Tal Korem Named an Early Career Global Scholar
Tal Korem, PhD, assistant professor of systems biology, has been named a CIFAR Azrieli Global Scholar, a fellowship that supports leading early-career researchers in science and technology. As a global scholar, Dr. Korem joins CIFAR’s Humans and the Microbiome research program, where his work will focus on harnessing human microbial communities to identify and develop novel diagnostic and therapeutic tools.
Research News
Detailed Map Gives Scientists a New Window into how Human-Infecting Viruses Work
Columbia University biologists leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect. The method, along with the data that it generated, has spawned a wealth of information toward improving our understanding of how viruses manipulate the cells that they infect and cause disease. Among its findings, the work uncovered a role for estrogen receptor in regulating Zika Virus infection, as well as links between cancer and the human papillomavirus. The research, led by Dr. Sagi Shapira, appears Aug. 29 in the journal, Cell.