The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Research NewsWhy Some Brain Tumors Respond to Immunotherapy
Fewer than 1 in 10 patients with glioblastoma respond to immunotherapy, which has shown remarkable success in the past few years in treating a variety of aggressive cancers. But there has been no way to know in advance which glioblastoma patients will respond. In a study, led by Raul Rabadan, PhD, researches have learned why some glioblastomas—the most common type of brain cancer—respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.
Research NewsProstate Cancer Grant Spotlights Columbia’s Aim to Deliver Precision Cancer Medicine
Columbia University Irving Medical Center experts in prostate cancer will lead a new team research project that tests a novel approach for personalized cancer treatment. The two-year project, funded by a $1 million Challenge Award from the Prostate Cancer Foundation, combines computational methods for targeted drug therapy, single-cell RNA sequencing and novel cancer immunotherapy. The combined approaches are behind a proof-of-concept clinical trial for patients at Bronx VA with lethal metastatic prostate cancer.
Awards and GrantsThe Gates Foundation Funds the Wang Lab’s Efforts in Global Health Study
Dr. Harris Wang and systems biology graduate student, Ravi Sheth, have been awarded a grant from the Bill and Melinda Gates Foundation to help advance a global health project aimed at reducing childhood mortality in sub-Saharan Africa. The project incorporates Dr. Wang’s innovative microbiome research techniques to study the antibiotic, Azithromycin, and understanding its role as an intervention for improving childhood survival rates in low-resource settings.
Awards and GrantsAdvancing the Use of Single-Cell Technology for Novel Brain Cancer Treatment
The Mark Foundation for Cancer Research has awarded Dr. Peter Sims an Emerging Leader Award and will support his work to advance a novel use of single-cell RNA sequencing to develop brain cancer treatments. Dr. Sims, an early contributor to the emerging field of single-cell RNA sequencing, is one of just eight recipients of the inaugural grant, given to promising early career scientists for projects aimed at unmet needs in cancer risk prediction, prevention and treatment.
Innovative Engine: Medical Research
Columbia University researchers are rewriting the course of scientific investigation, intent on speeding up the process of discovery that will help patients with cancer, Alzheimer’s disease, diabetes, and other intractable diagnoses. In cancer, Dr. Andrea Califano decided to turn cancer treatment theory on its head. In a feature published in the College of Physicians & Surgeons’ Annual Report, Dr. Califano’s work in precision cancer medicine is highlighted, along with the work of other Columbia innovators who are having an impact on medical research.