The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
Awards and GrantsThe Gates Foundation Funds the Wang Lab’s Efforts in Global Health Study
Dr. Harris Wang and systems biology graduate student, Ravi Sheth, have been awarded a grant from the Bill and Melinda Gates Foundation to help advance a global health project aimed at reducing childhood mortality in sub-Saharan Africa. The project incorporates Dr. Wang’s innovative microbiome research techniques to study the antibiotic, Azithromycin, and understanding its role as an intervention for improving childhood survival rates in low-resource settings.
Awards and GrantsAdvancing the Use of Single-Cell Technology for Novel Brain Cancer Treatment
The Mark Foundation for Cancer Research has awarded Dr. Peter Sims an Emerging Leader Award and will support his work to advance a novel use of single-cell RNA sequencing to develop brain cancer treatments. Dr. Sims, an early contributor to the emerging field of single-cell RNA sequencing, is one of just eight recipients of the inaugural grant, given to promising early career scientists for projects aimed at unmet needs in cancer risk prediction, prevention and treatment.
Innovative Engine: Medical Research
Columbia University researchers are rewriting the course of scientific investigation, intent on speeding up the process of discovery that will help patients with cancer, Alzheimer’s disease, diabetes, and other intractable diagnoses. In cancer, Dr. Andrea Califano decided to turn cancer treatment theory on its head. In a feature published in the College of Physicians & Surgeons’ Annual Report, Dr. Califano’s work in precision cancer medicine is highlighted, along with the work of other Columbia innovators who are having an impact on medical research.
Dr. Cory Abate-Shen Elected an AAAS Fellow
The American Association for the Advancement of Science has elected Dr. Cory Abate-Shen a 2018 Fellow, recognizing her work in the development of innovative mouse models to better understand how basic cellular mechanisms are co-opted in cancer and for her contributions to the field of cancer biology. A leader in genitourinary malignancies, Dr. Abate-Shen is particularly interested in advancing our understanding of the mechanisms and modeling of prostate and bladder tumors. She holds joint appointments in the Departments of Systems Biology, Medicine and Pathology & Cell Biology.
Research NewsNovel Method Identifies New Risk Genes for Developmental Disorders
The genetics of developmental disorders, such as congenital heart disease and autism, are highly complex. There are roughly 500 to 1,000 risk genes that can lead to each of these diseases, and to date, only about a few dozen have been identified. Focusing on haploinsufficiency, a key biological mechanism of genetic risk in developmental disorders, Dr. Yufeng Shen has developed a computational method that enables researchers to find new risk genes in these diseases.
Events and Seminars
January 24, 2019 - 9:00am
Multiple Guest Speakers
January 25, 2019 - 3:00pm
Peng Jiang, PhD(Dana Farber Cancer Institute)
January 30, 2019 - 3:00pm
Dr. Benjamin Cravatt(Scripps Research )