Executive Research Director, Center for Computational Biology and Bioinformatics
Assistant Professor, Department of Biomedical Informatics
Aris Floratos is an assistant professor in the Department of Biomedical Informatics and executive research director at the Center for Computational Biology and Bioinformatics. His lab develops collaborative bioinformatics software to support the analysis and visualization of genomic data from a wide range of domains (gene expression, sequence, protein structure, and systems biology). This software leverages standards-based middleware technologies to provide seamless access to remote data, annotation, and computational servers, enabling researchers with limited local resources to benefit from public infrastructure. The Floratos Lab is also developing innovative, systems biology-driven methodologies that offer improved power to detect the contribution of low-risk genetic factors to drug-induced serious adverse events (SAEs). In collaboration with an international network of investigators, the lab is leading the analysis of genome-wide genotyping and exome sequencing data for drug-induced disorders including serious skin rash, liver injury, cardiac arrhythmias, and osteonecrosis of the jaw. Finally, the Floratos Lab has developed motif discovery algorithms that have been used to study the underlying evolutionary architecture of genomic sequences.