Suvrajit Maji

Titles

Associate Research Scientist

Suvrajit received his Bachelor's and Master's degree in Mathematics and Computing from the Indian Institute of Technology, Kharagpur, India. He then received his Ph.D. degree in computational biology from Carnegie Mellon University under the mentorship of his thesis advisor Dr. Marcel P. Bruchez. His thesis topic was “Generative Models for Super-Resolution Single Molecule Microscopy Images of Biological Structures”. He moved to Columbia University to continue his postdoctoral research work under the mentorship of Dr. Joachim Frank, where he focused on developing advanced mathematical, computer vision, and machine learning techniques for studying the structure and dynamics of molecular machines such as the Ribosomes and determining high-resolution 3D structures from 2D cryo-EM image datasets.

His current research in the lab of Chaolin Zhang focuses on computational methods development and application to study RNA-protein binding interactions using CLIP sequencing datasets. He is also involved in developing machine learning & deep learning methods to model and study RNA-protein complex structures.


Education History

PhD, Carnegie Mellon University - Computational Biology

MSc (Integrated BS & MS), Indian Institute of Technology, Kharagpur, India - Mathematics and Computing


Publications

Sayan Bhattacharjee, Xiangsong Feng, Suvrajit Maji, Prikshat Dadhwal, Zhening Zhang, Zuben P. Brown, Joachim Frank. Time resolution in cryo-EM using a PDMS-based microfluidic chip assembly and its application to the study of HflX-mediated ribosome recycling. Cell. (2024). 

Evan Seitz, Francisco Acosta-Reyes, Suvrajit Maji, Peter Schwander and Joachim Frank. Recovery of Conformational Continuum from Single-particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth. IEEE Transactions on Computational Imaging. (2022).

Terra Sztain, Surl-Hee Ahn, Anthony T. Bogetti, Lorenzo Casalino , Jory A. Goldsmith, Evan Seitz, Ryan S. McCool, Fiona L. Kearns, Francisco Acosta-Reyes, Suvrajit Maji, Ghoncheh Mashayekhi, J. Andrew McCammon, Abbas Ourmazd, Joachim Frank, Jason S. McLellan, Lillian T. Chong, Rommie E. Amaro. A glycan gate controls opening of the SARS-CoV-2 spike protein. Nature Chemistry (2021). 

Suvrajit Maji and Joachim Frank. What’s in the Black Box? – A Perspective on Software in Cryo-electron Microscopy. Biophysical Perspectives. Biophysical Journal (2021). 

Suvrajit Maji, Hstau Liao, Ali Dashti, Ghoncheh Mashayekhi, Abbas Ourmazd, Joachim Frank. Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding. Journal of Chemical Information and Modeling (2020). Special Issue: Frontiers in CryoEM Modeling. 

Suvrajit Maji, Rezvan Shahoei, Klaus Schulten, Joachim Frank. Quantitative Characterization of Domain Motions in Molecular Machines. Journal of Physical Chemistry B (2017).