The Glenn Foundation Discovery Award was created to support research projects with strong potential to develop pioneering discoveries to understand the underlying biological mechanisms that govern normal human aging and its related physiological decline.

Dr. Wu’s Discovery Award is titled "Aging as a self-reinforcing feedback loop: investigate the role of noncoding translation" and aims to open new lines of research into the complex interplay between multiple hallmarks of aging. Learn more about his ongoing research at Columbia here.

Read full article on American Federation for Aging Research page and Eurek Alert! page.

Andrea Califano, Dr, the founding chair of the Department of Systems Biology, will be leaving the chair role this fall to launch an exciting new program in collaboration with multiple universities in the tri-state area. We look forward to sharing further details on this new endeavor soon. In the meantime, we are pleased to share that Harris Wang, PhD, another founding member of the department, has agreed to serve as the interim chair.

While Dr. Califano is leaving his post as chair, his lab will remain at Columbia and he will continue to be a full-time faculty member in systems biology, biochemistry & molecular biophysics, medicine, and biomedical informatics, as well as a member of the Herbert Irving Comprehensive Cancer Center. As Dr. Wang steps into his role as interim chair, Dr. Califano will work closely with him to ensure continuity during the leadership transition.

Dr. Wang is well respected within the department and widely acknowledged as a pioneer in the field of synthetic biology. He holds dual bachelor’s degrees in physics and applied mathematics from the Massachusetts Institute of Technology and a PhD in biophysics & medical engineering from Harvard University, where he served as an instructor in systems biology before joining the Columbia faculty in 2013. Dr. Wang's research focuses on advancing next-generation microbiome and cellular therapeutics using systems and synthetic biology approaches. His development of Multiplex Automated Genome Engineering (MAGE), a technique allowing rapid genome editing of microbial cells, was celebrated as a breakthrough in the field of synthetic biology in 2009. More recently, Dr. Wang has been recognized for his pioneering work in spatial mapping and precision editing of the gut microbiome and using CRISPR technologies to track and record transient cellular processes. He was named a Schaefer Research Scholar at VP&S in 2018, one of many honors he has received. He received the 2022 Vilcek Prize for Creative Promise in Biomedical Science, the Presidential Early Career Award for Scientists and Engineers (PECASE) from the White House, and the NIH Director’s Early Independence award.  

Brian J. Joseph, PhD, postdoc in Chaolin Zhang and Hynek Wichterle labs, was one of the five 2023 class New York Stem Cell Foundation postdoc fellows. Dr. Joseph is working to re-engineer RNA regulatory networks to create mature brain cells from stem cells that can be used to better understand neurodegenerative diseases as well as aging.  For details see