Research in the Department of Systems Biology often results in novel applications for studying biology or for improving the diagnosis, prediction, or treatment of human disease. Licensing for these technologies is managed through Columbia Technology Ventures , a technology transfer office located at Columbia University Irving Medical Center. The following is a list of technologies invented by Department of Systems Biology investigators that are currently available for licensing. 

To learn more about any of these technologies, contact techventures@columbia.edu .

Available Technologies

Diagnosing and treating aggressive prostate cancer
Lead Inventors: Cory Abate-Shen ,  Andrea Califano

Diagnostic tool for differentiating low-risk and high-risk prostate cancer using genetic biomarkers
Lead Inventor: Cory Abate-Shen

Human antibodies for immuno-histochemical analysis of prostate cancer
Lead Inventor: Cory Abate-Shen

Mouse antibodies for immuno-histochemical analysis of prostate cancer
Lead Inventor: Cory Abate-Shen

Mutant mice studied for early stage prostate carcinogenesis
Lead Inventor: Cory Abate-Shen

Breast cancer prognostic biomarker to improve chemotherapy decisions
Lead Inventor: Dimitris Anastassiou

Method to identify disease biomarkers from gene expression data using attractor metagenes
Lead Investigator: Dimitris Anastassiou

Identification of a gene expression signature associated with cancer metastasis allows early detection and drug targeting
Lead Inventor: Dimitris Anastassiou

Method of deriving disease biomarkers from publicly available gene expression data
Lead Inventor: Dimitris Anastassiou

Computational software for cancer diagnosis and prognosis
Lead Investigator: Dimitris Anastassiou

Identification of genes synergistically associated with disease from continuous gene expression data
Lead Inventors: Dimitris Anastassiou , John Watkinson

Microarray data analysis tool to improve understanding of disease phenotype
Lead Inventor: Dimitris Anastassiou

DNA visualization software
Lead Inventor: Dimitris Anastassiou

MatrixREDUCE: Software for quantifying the sequence specificity of nucleotide binding factors based on high-throughput genomic data
Lead Inventor: Harmen Bussemaker

Method for predicting gene expression by modeling transcription factor activity
Lead Inventor: Harmen Bussemaker

Biology research software for sequence specificity of nucleotide binding factors based on genomic data
Lead Inventor: Harmen Bussemaker

Network-based algorithm for identifying a drug's mechanism of action
Lead Inventor: Andrea Califano

Diagnostic and therapeutic target for brain tumor
Lead Inventors: Antonio Iavarone, Andrea Califano

Discovery of a novel microRNA in normal and tumor-related human B cells
Lead Inventors: Andrea Califano , Riccardo Dalla-Favera

A systems biology method to predict oncogenes and perturbation targets on a cellular level
Lead Inventor: Andrea Califano

Simple, naked-eye pathogen detection using bioengineered baker's yeast
Lead Inventor: Virginia Cornish

In vivo assembly of DNA fragments
Lead Inventors: Virginia Cornish , Laura Wingler

Generating enzymes with enhanced catalytic activity via cell-mediated directed evolution
Lead Inventor: Virginia Cornish

Bacteria strain for small-molecule drug testing
Lead Inventor: Virginia Cornish

A method for identifying molecule as being able to bind protein target in cell
Lead Inventor: Virginia Cornish

In vivo screen using chemical inducers of dimerization for engineered enzyme with substrate specificity
Lead Inventor: Virginia Cornish

In vivo screen using chemical inducers of dimerization
Lead Inventor: Virginia Cornish

High-throughput fluorescence polarization assay for detecting metabolites
Lead Inventor: Virginia Cornish

In vivo screen using chemical inducers of dimerization
Lead Inventor: Virginia Cornish

Algorithm and software for detecting potential structural interactions among proteins
Lead Inventor: Barry Honig

Nucleic acid modification with tools from Oxytricha
Lead Inventor: Laura Landweber

DNA-templated micelle system for delivery of therapeutic agents
Lead Inventor: Kam Leong

Nucleic acid scavengers to reduce inflammation
Lead Inventor: Kam Leong

Diagnostic model accurately predicts cancer drug responsiveness
Lead Inventor: Raul Rabadan

Estimation of allelic differences from high-throughput sequencing experiments
Lead Inventor: Raul Rabadan

Computational analysis of electronic health records to identify disease associations
Lead Inventor: Raul Rabadan

Algorithm for identification of small genomic insertions
Lead Inventor: Raul Rabadan

Identifying copy number alterations in high throughput sequencing of captured genomic material
Lead Inventor: Raul Rabadan

Genetic biomarker for anti-PD-1 immunotherapy resistance prediction in glioblastoma multiforme
Lead Inventor: Raul Rabadan

Frequency analysis of sequence data at low coverage assembly
Lead Inventor: Raul Rabadan

Genomic data represented as barcodes, to easily identify evolutionary patterns
Lead Inventor: Raul Rabadan

Universal donor yeast strain for transfer of genetic material
Lead Inventor: Rodney Rothstein

Cyclosporine targets PTEN-deficient cancer cells in a highly specific manner
Lead Inventor: Rodney Rothstein

Method for library construction by generating directed, recombinant fusion nucleic acids
Lead Inventor: Rodney Rothstein

Method for culturing patient-derived cancer cells expedites treatment decisions for bladder cancer
Lead Inventor: Michael Shen

Generation and culture of prostate tissues and organoids for drug screening and development
Lead Inventor: Michael Shen

Identification of stem cells as the cellular basis of prostate cancer provides therapeutic potential
Lead Inventor: Michael Shen

High throughput approach to protein identification
Lead Inventor: Peter Sims

Aptamer-based selection for multiple cell surface markers in a single step
Lead Inventor: Milan Stojanovic

Treatment for nerve agent poisoning through reactivation of acetylcholinesterase (AChE)
Lead Inventor: Milan Stojanovic

In situ derivatization of challenging targets enables solution phase aptamer selection
Lead Inventor: Milan Stojanovic

High throughput solid phase assay for acetylcholinesterase (AChE) activity
Lead Inventor: Milan Stojanovic

DNA-based device for orally controlled insulin delivery
Lead Inventors: Milan Stojanovic , Renjun Pei, Steven Kennedy

Molecular machines programmed to play games demonstrating high levels of molecular computational ability
Lead Inventor: Milan Stojanovic

Low-cost, rapid urinalysis diagnostic for metabolic disease
Lead Inventor: Milan Stojanovic

Fluorescence-based assay for detection and quantification of cytosolic molecules
Lead Inventor: Milan Stojanovic

Colorimetric assay for the detection of small molecules
Lead Inventor: Milan Stojanovic

Machine learning algorithm for predicting clinical trial success
Lead Inventor: Nicholas Tatonetti

Bioinformatic algorithm for automated family history retrieval and enhanced clinical care
Lead Inventor: Nicholas Tatonetti

NETwork-based analysis of genomic variations
Lead Inventor: Dennis Vitkup

Commensal microbe gene selection platform for efficient gut colonization
Lead Inventor: Harris Wang

MoSAIC: High-throughput, multiplex targeting of CRISPR/Cas9 to genomic loci
Lead Inventor: Harris Wang

Splicescope: a computational software for determining cellular states using RNA splicing profiles
Lead Inventor: Chaolini Zhang