The Izar research laboratory in the Herbert Irving Comprehensive Cancer Center and the Columbia Center for Translational Immunology (CCTI) is affiliated with the Program for Mathematical Genomics and the New York Genome Center. We aim to dissect interactions of cancer and immunity in the tumor development, metastasis and drug resistance using high-dimensional functional single-cell genomics and imaging. The ultimate goal of this work is to inform better selection and development of therapies to improve the lives of cancer patients.