Nicholas Tatonetti

Selected Publications

Glicksberg BS, Oskotsky B, Thangaraj PM, Giangreco N, Badgeley MA, Johnson KW, Datta D, Rudrapatna VA, Rappoport N, Shervey MM, Miotto R, Goldstein TC, Rutenberg E, Frazier R, Lee N, Israni S, Larsen R, Percha B, Li L, Dudley JT, Tatonetti NP, Butte AJ. PatientExploreR: an extensible application for dynamic visualization of patient clinical history from electronic health records in the OMOP common data model. Bioinformatics. 2019 Nov 1;35(21):4515-4518. doi: 10.1093/bioinformatics/btz409.

Lyudovyk O, Shen Y, Tatonetti NP, Hsiao SJ, Mansukhani MM, Weng C. Pathway analysis of genomic pathology tests for prognostic cancer subtyping. J Biomed Inform. 2019 Oct;98:103286. doi: 10.1016/j.jbi.2019.103286. 

Basile AO, Yahi A, Tatonetti NP. Artificial Intelligence for Drug Toxicity and Safety. Trends Pharmacol Sci. 2019 Sep;40(9):624-635. doi: 10.1016/

Polubriaginof FCG, Ryan P, Salmasian H, Shapiro AW, Perotte A, Safford MM, Hripcsak G, Smith S, Tatonetti NP, Vawdrey DK. Challenges with quality of race and ethnicity data in observational databases. J Am Med Inform Assoc. 2019 Aug 1;26(8-9):730-736. doi: 10.1093/jamia/ocz113.

Tatonetti NP. The Next Generation of Drug Safety Science: Coupling Detection, Corroboration, and Validation to Discover Novel Drug Effects and Drug-Drug Interactions. Clin Pharmacol Ther. 2018 Feb.

Macesic N, Polubriaginof F, Tatonetti NP. Machine learning: novel bioinformatics approaches for combating antimicrobial resistance. Curr Opin Infect Dis. 2017 Dec;30.

Yahi A, Vanguri R, Elhadad N, Tatonetti NP. Generative Adversarial Networks for Electronic Health Records: A Framework for Exploring and Evaluating Methods for Predicting Drug-Induced Laboratory Test Trajectories . 31st Conference on Neural Information Processing Systems (NIPS 2017) December 2017.

Moskovitch R, Polubriaginof F, Weiss A, Ryan P, Tatonetti NP. Procedure prediction from symbolic electronic health records via time intervals analytics. Journal of Biomedical Informatics; Nov. 2017.

Tatonetti NP. Translational medicine in the Age of Big Data. Briefings in Bioinformatics; Oct. 2017

Boland MR, Polubriaginof F, Tatonetti NP. Development of A Machine Learning Algorithm to Classify Drugs Of Unknown Fetal Effect. Sci Rep. 2017 Oct 9.

Boland MR, Parhi P, Li L, Miotto R, Carroll R, Iqbal U, Nguyen PA, Schuemie M, You SC, Smith D, Mooney S, Ryan P, Li YJ, Park RW, Denny J, Dudley JT, Hripcsak G, Gentine P, Tatonetti NP. Uncovering exposures responsible for birth season - disease effects: a global study. J Am Med Inform Assoc. 2017 Sep 28.

Boland MR, Parhi P, Gentine P, Tatonetti NP. Climate Classification is an Important Factor in Assessing Quality-of-Care Across Hospitals. Sci Rep. 2017 Jul 10.

Moskovitch R, Choi H, Hripcsak G, Tatonetti NP. Prognosis of clinical outcomes with temporal patterns and experiences with one class feature selection. IEEE/ACM transactions on computational biology and bioinformatics; May 2017.

Lorberbaum T, Tatonetti NP. Reply: Combination Therapy With Ceftriaxone and Lansoprazole, Acquired Long QT Syndrome and Torsades de Pointes Risk. J Am Coll Cardiol. 2017 Apr 11.

Chang JB, Quinnies KM, Realubit R, Karan C, Rand JH, Tatonetti NP.  A novel, rapid method to compare the therapeutic windows of oral anticoagulants using the Hill coefficient.  Sci Rep. 2016 Jul 21;6:29387.  

Moskovitch R, Choi H, Hripcsak G, Tatonetti NP.  Prognosis of clinical outcomes with temporal patterns and experiences with one class feature selection . IEEE/ACM Transactions on Computational Biology and Bioinformatics. Jul 2016. 
Lorberbaum T, Sampson KJ, Woosley RL, Kass RS, Tatonetti NP.  An integrative data science pipeline to identify novel drug interactions that prolong the QT interval.  Drug Saf. 2016 May;39(5):433-41.
Kidd BA, Wroblewska A, Boland MR, Agudo J, Merad M, Tatonetti NP, Brown BD, Dudley JT.  Mapping the effects of drugs on the immune system.  Nat Biotechnol. 2016 Jan;34(1):47-54.
Romano JD, Tatonetti NP.  VenomKB, a new knowledge base for facilitating the validation of putative venom therapies.  Sci Data. 2015 Nov 24;2:150065. 
Jacunski A, Dixon SJ, Tatonetti NP.  Connectivity homology enables inter-species network models of synthetic lethality.  PLoS Comput Biol. 2015 Oct 9;11(10):e1004506.
Boland MR, Shahn Z, Madigan D, Hripcsak G, Tatonetti NP.  Birth month affects lifetime disease risk: a phenome-wide method.  J Am Med Inform Assoc. 2015 Sep;22(5):1042-53.
Lorberbaum T, Nasir M, Keiser MJ, Vilar S, Hripcsak G, Tatonetti NP.  Systems pharmacology augments drug safety surveillance.  Clin Pharmacol Ther. 2015 Feb;97(2):151-8.
Vilar S, Ryan PB, Madigan D, Stang PE, Schuemie MJ, Friedman C, Tatonetti NP, Hripcsak G.  Similarity-based modeling applied to signal detection in pharmacovigilance.  CPT Pharmacometrics Syst Pharmacol. 2014 Sep 24;3:e137. 
Li L, Ruau DJ, Patel CJ, Weber SC, Chen R, Tatonetti NP, Dudley JT, Butte AJ.  Disease risk factors identified through shared genetic architecture and electronic medical records.  Sci Transl Med. 2014 Apr 30;6(234):234ra57. 
Karczewski KJ, Snyder M, Altman RB, Tatonetti NP.  Coherent functional modules improve transcription factor target identification, cooperativity prediction, and disease association.  PLoS Genet. 2014 Feb 6;10(2):e1004122.
Jacunski A, Tatonetti NP.  Connecting the dots: applications of network medicine in pharmacology and disease.  Clin Pharmacol Ther. 2013 Dec;94(6):659-69. 
Sun X, Vilar S, Tatonetti NP.  High-throughput methods for combinatorial drug discovery.  Sci Transl Med. 2013 Oct 2;5(205):205rv1.
White RW, Tatonetti NP, Shah NH, Altman RB, Horvitz E.  Web-scale pharmacovigilance: listening to signals from the crowd.  J Am Med Inform Assoc. 2013 May 1;20(3):404-8. 
Tatonetti NP, Ye PP, Daneshjou R, Altman RB.  Data-driven prediction of drug effects and interactions.  Sci Transl Med. 2012 Mar 14;4(125):125ra31.
Tatonetti NP, Fernald GH, Altman RB.  A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports.  J Am Med Inform Assoc. 2012 Jan-Feb;19(1):79-85. 
Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsao PS, Kohane I, Roden DM, Altman RB.  Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.  Clin Pharmacol Ther. 2011 Jul;90(1):133-42.
Karczewski KJ, Tirrell RP, Cordero P, Tatonetti NP, Dudley JT, Salari K, Snyder M, Altman RB, Kim SK.  Interpretome: a freely available, modular, and secure personal genome interpretation engine.  Pac Symp Biocomput. 2012:339-50. 
Karczewski KJ, Tatonetti NP, Landt SG, Yang X, Slifer T, Altman RB, Snyder M. Cooperative transcription factor associations discovered using regulatory variation . Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13353-8.
Tatonetti NP, Liu T, Altman RB.  Predicting drug side-effects by chemical systems biology.  Genome Biol. 2009;10(9):238.