HLA-IBD

Lead Investigator(s)
Itsik Pe'er
Description

The human leukocyte antigen (HLA) genes play a major role in adaptive immune response and are used to differentiate self cells from non-self cells. HLA genes are hyper-variable with nearly every locus containing over a dozen alleles. This variation plays an important role in autoimmune diesease and organ transplantation. HLA typing by serological methods is time-consuming and expensive. This computational method can be used to infer per-locus HLA types using shared segments that are identical by descent (IBD), inferred from genotype data.

Short Description

A method for inferring per-locus human leukocyte antigen types using shared segments that are identical by descent (IBD), inferred from genotype data.

Software Type
Genetic Data Analysis
PubMed ID
21385049