Graduate Research Assistant (MD/PhD)
I’m from Atlanta, GA and went to Georgia Tech majoring in Biochemistry. During college, I was involved in cancer drug development and cardiac tissue engineering research. After graduating in 2016, I worked for a few years at the NIH via the post-baccalaureate research program. At NIH I studied a rare primary immunodeficiency which dysregulates magnesium homeostasis in T cells and demonstrated how specific T cell receptor associated kinases are dependent on physiological Mg2+ concentrations to function optimally. I joined the MD/PhD program at Columbia in Fall 2019.
I am currently a graduate student in Peter Sims’s lab working on slice culture models of human lymph nodes to study basic questions in human immunology like T-cell activation/signaling and vaccination in lymphoid tissues. I utilize single cell RNA-seq approaches coupled with surface protein phenotyping (CITE-seq) along with conventional immunological assays and imaging modalities to study these immunological questions. We aim to define a reference T cell activation signature in healthy human tissue and use that as a baseline to compare against for disease and to better understand early events in the vaccination response.
In my free time I enjoy discovering and reading in many of NYC’s coffee shops/roasters, exploring the diverse food scene, or spending time outdoors (Central and Riverside Parks, hiking upstate).
- Kanellopoulou, C*., George, A*., Masutani. E., Cannons. J., Ravell, J. Lenardo. M. J., et. Al. (2019). “Mg 2+ regulation of kinase signaling and immune function.” Journal of Experimental Medicine. 216 (8): 1828–1842. doi.org/10.1084/jem.20181970. * Co-first authors.
- George, A., Raji, I., Cinar, B., Kucuk, O., Oyelere, A. (2018). “Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates.” Bioorganic & Medicinal Chemistry. pii: S0968-0896(17)32189-2. doi: 10.1016/j.bmc.2018.01.009.
- Agarwal, U., George, A., Bhutani, S., Ghosh-Choudhary, S., Maxwell, J.T., Brown, M.E., Metha, Y., Platt, M.O., Liang, Y., Sahoo, S., Davis. M.E. (2017). “Experimental, Systems, and Computational Approaches to Understanding the MicroRNA-Mediated Reparative Potential of Cardiac Progenitor Cell-Derived Exosomes from Pediatric Patients.” Circulation Research. Feb 17;120(4):701-712. doi: 10.1161/CIRCRESAHA.116.309935.
- Shoja-Taheiri, F., George, A., Agarwal, U., Platt, M., Gibson, G., Davis, M. E. (2019). “Using statistical modeling to understand and predict pediatric stem cell function”. Circ Genom Precis Med. Jun;12(6):e002403. doi: 10.1161/CIRCGEN.118.002403.
- Agarwal, U., Smith, A., French, K., Boopathy, A., George, A., Trac, D., Davis, M.E., et. Al. (2016). "Age-dependent effect of pediatric cardiac progenitor cells following juvenile heart failure." Stem Cells Translational Medicine. Jul;5(7):883-92. doi: 10.5966/sctm.2015-0241. Epub 2016 May 5.
- Washington, A., Tapadar, S., George, A., Oyelere, AK. (2015). Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. Bioorganic & Medicinal Chemistry, 23(16):5198-209.