Boris Grinshpun

Boris Grinshpun


Graduate Student

Boris Grinshpun is a PhD student in the Integrated Program in Cellular, Molecular, and Biomedical Studies at Columbia University. He holds a BS in applied mathematics as well as an MA and an MPhil in computational biology from Columbia.

Boris first became interested in applying his mathematics toolbox to interesting questions in biology while working in the lab of Chris Wiggins in the Department of Applied Mathematics during his junior year of college. He currently works in the laboratory of Yufeng Shen, where his research focuses on the statistical analysis and mathematical modeling of the T cell receptor repertoire. In particular, he works with several experimental collaborators to investigate 1) changes in T cell repertoire diversity during the progression of gliomas both in human brain tissue and using murine models and 2) tissue specific compartmentalization and repertoire differences in human effector memory T cell subsets. His goal is ultimately to make important breakthroughs in understanding the complex relationship between immunity and disease.

Education History

MPhil, Columbia University
Computational Biology

MA, Columbia University
Computational Biology 

BS, Columbia University
Applied Mathematics


Sims JS, Grinshpun B, Feng Y, Ung TH, Neira JA, Samanamud JL, Canoll P, Shen Y, Sims PA, Bruce JN. Diversity and divergence of the glioma-infiltrating T-cell receptor repertoire. Proc Natl Acad Sci U S A. 2016 Jun 3.

Thome JJ, Yudanin N, Ohmura Y, Kubota M, Grinshpun B, Sathaliyawala T, Kato T, Lerner H, Shen Y, Farber DL. Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell. 2014 Nov 6;159(4):814-28.

Grinshpun B, Sims J, Feng Y, Canoll P, Sims P, Bruce JN, Shen Y. Analyzing T cell receptor repertoire diversity by high-throughput sequencing.  IEEE GlobalSIP, 2013.

Grinshpun B, Sims J, Feng Y, Canoll P, Sims P, Bruce JN, Shen Y. High throughput sequence analysis of the TCR repertoire in glioma-associated immune dysregulation. American Society of Human Genetics, 2013.

Sims JS, Grinshpun B, Amendolara BI, Shen Y, Canoll PD, Sims PA, Bruce JN. Tumor-associated T cell receptor repertoires in low- and high-grade gliomas. J Immunother Cancer 2013;1(Suppl 1): P143.

Mugler A, Grinshpun B, Franks R, Wiggins CH. Statistical method for revealing form-function relations in biological networks. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):446-51.

Graham N, Wolfson SS, Kwok I, Grinshpun B"Buffy contrast adaptation" with a single Gabor patchJ Vision 2010 Aug 2;10(7):1386.