Chaitanya Rastogi

Chaitanya Rastogi


Associate Research Scientist

I am currently an associate research scientist at Columbia University in Harmen Bussemaker’s laboratory, where I also performed my doctoral work. My research is focused on developing biophysics-based models for describing biopolymer interactions using high-throughput sequencing data.

Education History

PhD, Columbia University
Applied Physics

MS, California Institute of Technology
Electrical Engineering

BS, California Institute of Technology
Applied Physics


Kribelbauer JF, Loker RE, Feng S, Rastogi C, Abe N, Rube HT, Bussemaker HJ, Mann RS. Context-dependent gene regulation by homeodomain transcription factor complexes revealed by shape-readout deficient proteins. Mol Cell. 2020 Apr 2;78(1):152-67.

Kribelbauer JF, Rastogi C, Bussemaker HJ, Mann RS. Low-affinity binding sites and the transcription factor specificity paradox in eukaryotes. Annu Rev Cell Dev Bi. 2019 Oct 6;35:357-79.

Sánchez-Higueras C, Rastogi C, Voutev R, Bussemaker HJ, Mann RS, Hombría JC.  In vivo Hox binding specificity revealed by systematic changes to a single cis regulatory module. Nature communications. 2019 Aug 9;10(1):1-3.

Rastogi C, Rube HT, Kribelbauer JF, Crocker J, Loker RE, Martini GD, Laptenko O, Freed-Pastor WA, Prives C, Stern DL, Mann RS. Accurate and sensitive quantification of protein-DNA binding affinity. P Natl Acad Sci USA. 2018 Apr 17;115(16):E3692-701.

Rube HT, Rastogi C, Kribelbauer JF, Bussemaker HJ. A unified approach for quantifying and interpreting DNA shape readout by transcription factors. Mol Syst Biol. 2018 Feb;14(2):e7902.

Zhang L, Martini GD, Rube HT, Kribelbauer JF, Rastogi C, FitzPatrick VD, Houtman JC, Bussemaker HJ, Pufall MA. SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site. Genome Res. 2018 Jan 1;28(1):111-21.

Rao S, Carolina Dantas Machado A, Zhou T, Rastogi C, Bussemaker HJ, Rohs R. 22 evolving insights on how cytosine methylation affects protein-DNA binding. J Biomol Struct Dyn. 2015 May;33 Suppl 1:12.

Dantas Machado AC, Zhou T, Rao S, Goel P, Rastogi C, Lazarovici A, Bussemaker HJ, Rohs R. Evolving insights on how cytosine methylation affects protein-DNA binding. Brief Funct Genomics. 2014 Oct 14. 

Riley T, Slattery M, Abe N, Rastogi C, Mann R, Bussemaker H. SELEX-seq: a method for characterizing the complete repertoire of binding site preferences for transcription factor complexes. In Hox Genes. Methods in Molecular Biology, Vol. 1196. Y. Graba and R. Rezsohazy, Eds. New York: Springer. 2014. 

Hodges JS, Yao NY, Mclaurin D, Rastogi C, Lukin MD, Englund D. Timekeeping with electronic spin states in diamond. Phys Rev A. 2013 Mar;87(3):032118.

Bandyopadhyay D, Sharma A, Rastogi C. Dewetting of the thin liquid bilayers on topographically patterned substrates: formation of microchannel and microdot arrays. Langmuir. 2008 Dec 16;24(24)14048-58.