Chao Hou


Postdoctoral Research Scientist

Chao is a postdoctoral research scientist at Dr. Yufeng Shen lab, studying computational biology and human genetics. He's currently working on developing first principle driven protein embedding models, and is also interested in investigating the functions and pathogenic mutations of disordered regions.
Chao received a PhD degree of Bioinformatics from Peking Univeristy with Dr. Tingting Li. During that time, Chao developed computational tools to investigate phase separation and protein degradation.

Personal website:

Education History

Sep 2020 - Jul 2023, Peking University, PhD of Bioinformatics
Sep 2015 - Jul 2020, Peking University, Bachelor of Medicine and Economics


Hou C, Wang X, Xie H, Chen T, Zhu P, Xu X, You K, Li T. PhaSepDB in 2022: annotating phase separation-related proteins with droplet states, co-phase separation partners and other experimental information. Nucleic Acids Res. 2023 Jan 6;51(D1):D460-D465

Hou C, Li Y, Wang M, Wu H, Li T. Systematic prediction of degrons and E3 ubiquitin ligase binding via deep learning. BMC Biology. 2022 Jul 14;20(1):162.

Hou C, Xie H, Fu Y, Ma Y, Li T. MloDisDB: a manually curated database of the relations between membraneless organelles and diseases. Brief Bioinform. 2021 Jul 20;22(4):bbaa271. 

Chen Z, Hou C, Wang L, Yu C, Chen T, Shen B, Hou Y, Li P, Li T. Screening membraneless organelle participants with machine-learning models that integrate multimodal features. Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2115369119. 

Zhu P, Hou C, Liu M, Chen T, Li T, Wang L. Investigating phase separation properties of chromatin-associated proteins using gradient elution of 1,6-hexanediol. BMC Genomics. 2023 Aug 28;24(1):493.

Han P, Hou C, Zheng X, Cao L, Shi X, Zhang X, Ye H, Pan H, Liu L, Li T, Hu F, Li Z. Serum Antigenome Profiling Reveals Diagnostic Models for Rheumatoid Arthritis. Front Immunol. 2022 Apr 20;13:884462.