Erin Bush


Director, Single Cell Core and Columbia Genome Center

Erin Bush is the Director of the Single Cell Core and Columbia Genome Center. She has been with the Genome Center since 2011 and founded the Single Cell Core with Peter Sims in 2017. She is responsible for day-to-day operations of both cores, as well as all administrative aspects of the Single Cell Core.

Related News

Erin Bush Receives College of Physicians & Surgeons Officer of Research Award

Education History

MHA, Mailman School of Public Health

MA, Biotechnology, Columbia Graduate School of Arts and Sciences

BA, Molecular Biology, Princeton University


Pan H, Xue C, Auerbach BJ, Fan J, Bashore AC, Cui J, Yang DY, Trignano SB, Liu W, Shi J, Ihuegbu CO, Bush EC, Worley J, Vlahos L, Laise P, Solomon RA, Connolly ES, Califano A, Sims PA, Zhang H, Li M, Reilly MP. Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human. Circulation. 2020 Nov 24;142(21):2060-2075.

Capdevila C, Calderon RI, Bush EC, Sheldon-Collins K, Sims PA, Yan KS. Single-Cell Transcriptional Profiling of the Intestinal Epithelium. Methods Mol Biol. 2020;2171:129-153.

Szabo PA, Levitin HM, Miron M, Snyder ME, Senda T, Yuan J, Cheng YL, Bush EC, Dogra P, Thapa P, Farber DL, Sims PA. Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease. Nat Commun. 2019 Oct 17;10(1):4706.

Luchsinger LL, Strikoudis A, Danzl NM, Bush EC, Finlayson MO, Satwani P, Sykes M, Yazawa M, Snoeck HW. Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro. Cell Stem Cell. 2019 Aug 1;25(2):225-240.e7.

Levitin HM, Yuan J, Cheng YL, Ruiz FJ, Bush EC, Bruce JN, Canoll P, Iavarone A, Lasorella A, Blei DM, Sims PA. De novo gene signature identification from single-cell RNA-seq with hierarchical Poisson factorization. Mol Syst Biol. 2019 Feb 22;15(2):e8557.

Yuan J, Levitin HM, Frattini V, Bush EC, Boyett DM, Samanamud J, Ceccarelli M, Dovas A, Zanazzi G, Canoll P, Bruce JN, Lasorella A, Iavarone A, Sims PA. Single-cell transcriptome analysis of lineage diversity in high-grade glioma. Genome Med. 2018 Jul 24;10(1):57.

Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J. Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma. PLoS One. 2018 May 22;13(5):e0190001. 

Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. Oncotarget. 2017 Apr 18;8(32):52474-52487.

Bush EC, Ray F, Alvarez MJ, Realubit R, Li H, Karan C, Califano A, Sims PA. PLATE-Seq for genome-wide regulatory network analysis of high-throughput screens. Nat Commun. 2017 Jul 24;8(1):105. 

Pino P, Sebastian S, Kim EA, Bush E, Brochet M, Volkmann K, Kozlowski E, Llinás M, Billker O, Soldati-Favre D. A tetracycline-repressible transactivator system to study essential genes in malaria parasites. Cell Host Microbe. 2012 Dec 13;12(6):824-34.