Postdoctoral Research Scientist
I am a PostDoctoral Research Scientist in the laboratory of Dr. Dennis Vitkup working to develop probabilistic methods for studying mechanistic models of cell signaling. Given the complexity of the models that describe signaling cascades and insufficiency of available experimental data, such models are vastly underdetermined and therefore call for the use of probabilistic simulations. We apply our methodology to study signaling cascades initiated by epidermal growth factor receptors, a family of proteins often implicated in cancer. Ultimately, we want to understand how complex relationships between signaling components produce observed cell functions. In addition, we want to be able to predict cell response to anti-EGFR drugs.
PhD, Columbia University
MA, Columbia University
BS, Massachusetts Institute of Technology
Math with Computer Science
Lim WK, Lyashenko E, Califano A. Master regulators used as breast cancer metastasis classifier. Pac Symp Biocomput. 2009;14:504–515.
Bern M, Goldberg D, Lyashenko E. Data mining for proteins characteristic of clades. Nucleic Acids Res. 2006;34:4342–4353.