Jared Sampson is a Ph.D. student in the Integrated Program in Cellular, Molecular and Biomedical Studies. He arrived at Columbia in 2015 after a decade in academic research labs as a research assistant and technician. He is a member of the Shapiro lab as well as the Friesner lab in the department of Chemistry. His research includes experimental and computational studies of the molecular basis of protein-protein binding interactions in Drosophila embryonic cell surface receptors and in human antibody complexes.
Jiang X, Totrov M, Li W, Sampson JM, Williams C, Lu H, Wu X, Lu S, Wang S, Zolla-Pazner S, and Kong XP. "Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits.” J. Virology. 2016; 90(24):11007-11019. Yelshanskaya MV, Singh AK, Sampson JM, Narangoda C, Kurnikova M, Sobolevsky AI. “Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.” Neuron. 2016; 91(6):1305-15. Killikelly A, Benson MA, Ohneck EA, Sampson JM, Jakoncic J, Spurrier B, Torres VJ, Kong XP. “Structure-based functional characterization of Repressor of Toxin (Rot), a central regulator of Staphylococcus aureus virulence.” J. Bacteriol. 2015; 197(1):188-200. Spurrier B, Sampson J, Gorny MK, Zolla-Pazner S, Kong XP. “Functional Implications of the Binding Mode of a Human Conformation-Dependent V2 Monoclonal Antibody against HIV.” J. Virol. 2014; 88(8):4100-12. Pan R, Sampson JM, Chen Y, Vaine M, Wang S, Lu S, Kong XP. “Rabbit anti-HIV-1 monoclonal antibodies raised by immunization can mimic the antigen-binding modes of antibodies derived from HIV-1 infected humans.” J. Virol. 2013; 87(18) 10221-10231. Gorny MK, Sampson J, Li H, Jiang X, Totrov M, Wang XH, Williams C, O'Neal T, Volsky B, Li L, Cardozo T, Nyambi P, Zolla-Pazner S, Kong XP. “Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure.” PLoS ONE. 2011; 6(12): e27780. Spurrier B, Sampson JM, Totrov M, Li H, O'Neal T, Williams C, Robinson J, Gorny MK, Zolla-Pazner S, Kong XP. “Structural analysis of human and macaque mAbs 2909 and 2.5B: implications for the configuration of the quaternary neutralizing epitope of HIV-1 gp120.” Structure. 2011; 19(5): 691-9. Sampson JM, Ke W, Bethel CR, Pagadala SR, Nottingham MD, Bonomo RA, Buynak JD, van den Akker F. “Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.” Antimicrob. Agents Chemother. 2011; 55(5): 2303-9. Ke W, Sampson JM, Ori C, Prati F, Drawz SM, Bethel CR, Bonomo RA, van den Akker F. “Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors.” Antimicrob. Agents Chemother. 2011; 55(1): 174-83. Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD. “Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase. Journal of Amer Chem Soc 132(38) 13320-13331.