Systems Biology Fellow
I am interested in combining my training in quantitative engineering and experimental molecular biology to reverse engineer complex biological systems and to develop novel solutions to public health challenges. I am particularly interested in finding ways to address the growing problem of bacterial resistance to antibiotics. In collaboration with the Tavazoie Lab, I am developing techniques for rapidly characterizing protein-DNA interactions and experimental approaches for characterizing the physiology of transient cellular states that arise from population heterogeneity.
Postdoctoral Position Available
The Allison Lab is seeking a postdoc with quantitative research experience. Interested candidates should email a CV, summary of research interests, and a list of three references to Dr. Allison.
Prestigious NIH Directors Awards Go to Two Department of Systems Biology Researchers
Kyle Allison was named a 2014 recipient of the NIH Director's Early Independence Award.
PhD, Boston University
BSE, University of Michigan
Allison KR, Collins JJ. Bacteria as control engineers. Mol Cell. 2011 Jan 7;41(1):4-5.
Allison KR, Brynildsen MP, Collins JJ. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature. 2011 May 12;473(7346):216-20.
Allison KR, Brynildsen MP, Collins JJ. Heterogeneous bacterial persisters and engineering approaches to eliminate them. Curr Opin Microbiol. 2011 Oct;14(5):593-8.
Vega NM, Allison KR, Khalil AS, Collins JJ. Signaling-mediated bacterial persister formation. Nat Chem Biol. 2012 Mar 18;8(5):431-3. (http://www.nature.com/nchembio/journal/v8/n5/full/nchembio.915.html)
Marbach D, Costello JC, Küffner R, Vega NM, Prill RJ, Camacho DM, Allison KR; DREAM5 Consortium, Kellis M, Collins JJ, Stolovitzky G. Wisdom of crowds for robust gene network inference. Nat Methods. 2012 Jul 15;9(8):796-804.
Vega NM, Allison KR, Samuels AN, Klempner MS, Collins JJ. Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14420-5.
Vega NM, Allison KR, Samuels AN, Klempner MS, Collins JJ. Reply to Blair et al.: Dose-dependent effects and oxidative stress responses in antibiotic tolerance in Salmonella typhimurium. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4570. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845158/)
Dwyer DJ, Belenky PA, Yang JH, MacDonald IC, Martell JD, Takahashi N, Chan CT, Lobritz MA, Braff D, Schwarz EG, Ye JD, Pati M, Vercruysse M, Ralifo PS, Allison KR, Khalil AS, Ting AY, Walker GC, Collins JJ. Antibiotics induce redox-related physiological alterations as part of their lethality. Proc Natl Acad Sci U S A. 2014 May 20;111(20):E2100-9.