Luca Zanella


Postdoctoral Research Scientist

Luca is a Chemical Engineer who graduated (BS 2016, MS 2018) and completed his PhD (2023) from University of Padova, Italy. His doctoral research focused on the development of computational models to study the role of tumor-derived extracellular vesicles in cancer dissemination and metastasis. During the last year of his PhD, Luca joined Dr. Andrea Califano’s Lab at the Department of Systems Biology, where he is currently doing is postdoctoral training. His research lies at the interface between systems biology, precision medicine and computer science and involves the development and application of network-based computational methodologies to study tumor heterogeneity in the context of IDH-mutant gliomas and to dissect cancer cell adaptation mechanisms from perturbational data at single-cell resolution in several tumor contexts.

Education History

PhD in Chemical Engineering, University of Padova, Italy (10/2019 – 05/2023)

M.S. in Chemical Engineering, University of Padova, Italy (10/2016 – 10/2018)

B.S. in Chemical Engineering, University of Padova, Italy (10/2013 – 07/2016)


Fusco P, Fietta A, Esposito MR, Zanella L , Micheli S, Bastianello A, Bova L, Borile G, Germano G, Cimetta E. miR-210-3p enriched extracellular vesicles from hypoxic neuroblastoma cells stimulate migration and invasion of target cells. Cell Biosci. 2023.

Vasciaveo A, Arriaga JM, Nunes de Almeida F, Zou M, Douglass EF, Picech F, Shibata M, Rodriguez-Calero A, de Brot S, Mitrofanova A, Chua CW, Karan C, Realubit R, Pampou S, Kim JY, Afari SN, Mukhammadov T, Zanella L , Corey E, Alvarez MJ, Rubin MA, Shen MM, Califano A, Abate-Shen C. OncoLoop: A network-based precision cancer medicine framework. Cancer Discov. 2023.

Zanella L, Facco P, Bezzo F, Cimetta E. Feature Selection and Molecular Classification of Cancer Phenotypes: A Comparative Study. Int. J. Mol. Sci. 2022; 23(16):9087

Zingales V, Torriero N, Zanella L, Fernández-Franzón M, Ruiz MJ, Esposito MR, Cimetta E. Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing. Food Chem Toxicol. 2021.