Pasquale Laise

Pasquale Laise


Adjunct Associate Research Scientist

Pasquale is a computational biologist with an interdisciplinary background, holding a master’s degree in Biology and a PhD in Nonlinear Dynamics and Complex Systems. His expertise is in cancer and epigenetics with focus on the mechanistic aspects underlying cancer initation and progression. Prior to joining Columbia, Pasquale was a postdoctoral fellow in the Giuseppe Testa lab at the European Institute of Oncology in Milan, Italy and a visiting postdoc in the Jason Ernst lab at University of California, Los Angeles.

Education History

PhD, University of Florence                                                                                                       Nonlinear Dynamics and Complex Systems

Master's Degree, University of Florence                                                                                    Biological Sciences

Bachelor's Degree,University of Calabria                                                                                   Biological Sciences


PL Germain, A Vitriolo, A Adamo, P Laise, V Das, G Testa. RNAontheBENCH: computational and empirical resources for benchmarking RNAseq quantification and differential expression methods. Nucleic Acids Res (2016) 44 (11): 5054-50672016.

Elena Signaroldi*, Pasquale Laise*, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa.Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network. Nature Communications 7, Article number: 10753 (2016) doi:10.1038/ncomms10753.

Giulia Fragola, Pierre-Luc Germain, Pasquale Laise, Alessandro Cuomo, Alessandro Blasimme, Fridolin Gross, Elena Signaroldi, Gabriele Bucci, Cesar Sommer, Giancarlo Pruneri, Giovanni Mazzarol, Tiziana Bonaldi, Gustavo Mostoslavsky, Stefano Casola, Giuseppe Testa. Cell reprogramming requires silencing of a core subset of polycomb targets PLoS Genet, February 28, 2013.

Marika Masselli, Pasquale Laise, Giulia Tonini, Duccio Fanelli, Serena Pillozzi, Valentina Cetica, Martina Da Ros, Iacopo Sardi, Anna Maria Buccoliero, Maurizio Aricò, Lorenzo Genitori, Andrea Becchetti, Annarosa Arcangeli.Deregulation of ion channel and transporter encoding genes in pediatric gliomas. Frontiers in oncology, 30 May 2012 |

Pasquale Laise, Duccio Fanelli, Annarosa Arcangeli.A dynamical model of apoptosis and its role in tumor progression. Communications in Nonlinear Science and Numerical Simulation 17 (4), 1795-1804.

Pasquale Laise, Duccio Fanelli, Pietro Lió, Annarosa Arcangeli. Modeling TGF-β signaling pathway in epithelial-mesenchymal transition. AIP Advances 2, 011201 (2012); doi:

Pasquale Laise, Francesca Di Patti, Duccio Fanelli, Marika Masselli, Annarosa Arcangeli. Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony Journal of Theoretical Biology, Volume 272, Issue 1, 7 March 2011, Pages 55–63.