Wenxing Li

Titles

Postdoctoral Research Scientist

Wenxing Li is a Postdoctoral Research Scientist at the Columbia University Department of Systems Biology, specializing in bioinformatics and systems biology. His work focuses on discovering new risk genes and the genetic etiology of developmental diseases through the integration of single-cell omics, machine learning, and genetics approaches. Recently, he identified novel congenital heart disease risk genes by integrating large-scale exome sequencing data. He has also developed a machine learning model for predicting autism risk genes by leveraging large-scale single-cell transcriptomic data from human brain development.


Education History

2017–2020 Ph.D. in Neurobiology, Kunming Institute of Zoology, Chinese Academy of Sciences

2014–2017 M.S. in Cell Biology, Anhui University

2010–2014 B.S. in Biological Sciences & B.E. in Software Engineering, Anhui University


Publications

Rao L, Li W, Shen Y, Chung WK, Gennerich A. Distinct Clinical Phenotypes in KIF1A-Associated Neurological Disorders Result from Different Amino Acid Substitutions at the Same Residue in KIF1A. Biomolecules. 2025 May 2;15(5):656. 

Sudnawa KK, Pini N, Li W, Kanner CH, Ryu J, Calamia S, Bain JM, Goldman S, Montes J, Shen Y, Chung WK. Clinical characteristics, longitudinal adaptive functioning, and association with electroencephalogram activity in PPP2R5D-related neurodevelopmental disorder. Clin Genet. 2025 Jan;107(1):34-43.

Xu C, Bao S, Wang Y, Li W, Chen H, Shen Y, Jiang T, Zhang C. Reference-informed prediction of alternative splicing and splicing-altering mutations from sequences. Genome Res. 2024 Aug 20;34(7):1052-1065.

Sudnawa KK, Li W, Calamia S, Kanner CH, Bain JM, Abdelhakim AH, Geltzeiler A, Mebane CM, Provenzano FA, Sands TT, Fee RJ, Montes J, Shen Y, Chung WK. Heterogeneity of comprehensive clinical phenotype and longitudinal adaptive function and correlation with computational predictions of severity of missense genotypes in KIF1A-associated neurological disorder. Genet Med. 2024 Aug;26(8):101169.