Yao Shen

Yao Shen


Director of Systems Pharmacology, DarwinHealth

I am currently an Associate Research Scientist in the Califano Lab. My recent research has focused on drug functional mechanism of action (MoA) analysis and drug synergy prediction based on reverse engineering of cancer transcriptional and signaling networks. I am also working on a project on reversing drug resistance. Prior to joining Dr. Califano's lab, I was a member from Olaf Wiest's group at the University of Notre Dame, where I mainly worked on computer-aided drug design.

Education History

PhD, University of Notre Dame

MSc, University of Notre Dame
Computer Science & Engineering

BSc, Nanjing University, China


Alvarez MJ, Shen Y, Giorgi FM, Lachmann A, Ding BB, Ye BH, Califano A. Functional characterization of somatic mutations in cancer using network-based inference of protein activity. Nat Genet. 2016 Jun 20.

Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.

Shen Y, Liu J, Estiu G, Isin B, Ahn YY, Lee DS, Barabási AL, Kapatral V, Wiest O, Oltvai ZN. Blueprint for antimicrobial hit discovery targeting metabolic networks. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1082-7.

Xu S, Ge HM, Song YC, Shen Y, Ding H, Tan RX. Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem Biodivers. 2009 May;6(5):739-45. 

Ge HM, Shen Y, Zhu CH, Tan SH, Ding H, Song YC, Tan RX. Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp. Phytochemistry. 2008 Jan;69(2):571-6.