The Columbia NYSTEM High-Throughput Screening and Chemistry Shared Core Facility makes high-throughput discovery, as well as associated reagents and resources, available to all Columbia University and NYSTEM researchers. The automation and miniaturization technologies we maintain  make it possible for you to perform highly efficient and accurate screens for active chemical compounds, as well as mechanistic analysis using chemical biology or shRNA/siRNA approaches.  In addition, we maintain partnerships with experienced organic chemists that can help to move your research beyond the basic discovery stage toward the development of novel chemical compounds for specific targets of interest. We strive to provide these services at a cost that is within reach of all investigators. 

Please join us to learn about the state-of-the-art resources that the Columbia NYSTEM High-Throughput Screening and Chemistry Shared Core Facility provides, and for a series of scientific talks explaining how new, innovative high-throughput screening and chemistry approaches are leading to novel discoveries across a range of fields. Lunch will be provided for all registrants.

Register Here

There is no cost for attending this event, but we ask that all guests register in advance. Please use the form below and bring your ticket with you to the event.

Agenda

Registration

9:00 AM

Scientific Talks - Session 1

9:30 - 10:00 AM

Andrea Califano
Chair, Department of Systems Biology 
Elucidating Drug Mechanism of Action and Synergy in Cancer Cells

Presentation of the Facilities

10:00 - 10:45 AM
Christopher Henderson
Columbia Stem Cell Initiative
Stem Cell Models and High-Throughput Biology

Charles Karan /  Andrea Califano
NYSTEM High-Throughput Screening Facility

Rachid Skouta / Brent Stockwell
NYSTEM Chemical Probe Synthesis Facility

Alison Rinderspacher / Donald Landry
Organic Chemistry Collaborative Center

Scientific Talks - Session 2

10:45 AM - 12:30 PM

Fiona Doetsch
Associate Professor, Columbia Neuroscience
Adult Neural Stem Cell Regulation: Insights from Small Molecule Screening

Clarissa Waites
Associate Professor, Columbia Neuroscience
Screening Platform for the Discovery of Fluorescent Synaptic Markers

Marie-Laure Rives
Associate Research Scientist, Javitch Lab
Development of Selective Biased Ligands at the Kappa Opioid Receptor

Lunch, Poster Session, Vendor Stands, and Facilities Visit

12:30 - 2:00 PM

Scientific Talks - Session 3

2:00 - 3:30 PM

Ottavio Arancio
Associate Professor, Pathology and Cell Biology 
Alzheimer's Disease: Defeating It at the Synapse

Diane Ré
Associate Research Scientist, Przedborski Lab
Neuroprotective Small Molecules for the Treatment of Amyotrophic Lateral Sclerosis

Qing Fan
Assistant Professor, Pharmacology and Pathology and Cell Biology
Structural Mechanism of Ligand Activation in the Human GABA(B) Receptor

Keynote Address

3:30 - 4:15 PM

Lee Rubin
Harvard Stem Cell Institute
A Tale of Two Motor Neuron Diseases: ALS and SMA