Behind the Technique: Systems Biology with Andrea Califano
At the 2019 annual meeting of the American Association for Cancer Research (AACR), Dr. Andrea Califano sat down with BioTechniques News for an overview on the field of systems biology and its impact in cancer research and in precision medicine. Dr. Califano is a pioneering researcher in the field of systems biology whose expertise is in developing innovative, systematic approaches to identify the molecular factors that lead to cancer progression and to the emergence of drug resistance at the single-cell level. Dr. Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology and founding chair of the Department of Systems Biology at Columbia.
Targeting Cancer and Careers: Precision Medicine
In the field of oncology, innovations continue to grow rapidly in precision, or targeted medicine, as clinicians seek to find better treatments for specific kinds of cancer, rather than take a blanket approach to treating patients. This emerging direction in medicine and cancer research has also given birth to a flood of new jobs in previously unseen areas such as business, translational medicine and genetic counseling. Science magazine recently spoke to Andrea Califano, Dr, founding chair of the Department of Systems Biology and a pioneering researcher in this space, to get his thoughts about the rapidly growing field of precision medicine.
Prostate Cancer Grant Spotlights Columbia’s Aim to Deliver Precision Cancer Medicine
Columbia University Irving Medical Center experts in prostate cancer will lead a new team research project that tests a novel approach for personalized cancer treatment. The two-year project, funded by a $1 million Challenge Award from the Prostate Cancer Foundation, combines computational methods for targeted drug therapy, single-cell RNA sequencing and novel cancer immunotherapy. The combined approaches are behind a proof-of-concept clinical trial for patients at Bronx VA with lethal metastatic prostate cancer.
Innovative Engine: Medical Research
Columbia University researchers are rewriting the course of scientific investigation, intent on speeding up the process of discovery that will help patients with cancer, Alzheimer’s disease, diabetes, and other intractable diagnoses. In cancer, Dr. Andrea Califano decided to turn cancer treatment theory on its head. In a feature published in the College of Physicians & Surgeons’ Annual Report, Dr. Califano’s work in precision cancer medicine is highlighted, along with the work of other Columbia innovators who are having an impact on medical research.
Columbia Team Awarded New Prostate Cancer Grant for Innovative Precision Cancer Research
The Prostate Cancer Foundation (PCF) has announced more than $5.5 million in research funding to six new 2018 PCF Challenge Award teams, including an interdisciplinary team at Columbia University Irving Medical Center. The Columbia team includes Systems Biology faculty Drs. Michael Shen, Andrea Califano and Cory Abate-Shen, with several leading investigators from the Herbert Irving Comprehensive Cancer Center, the James J. Peters Veterans Affairs Medical Center and Dana-Farber Cancer Institute.