The goal of my current research is to integrate protein structure, lipidomics, and proteomics- and genomics-based networks to study cellular signaling pathways dysregulated in cancer. The work builds in part, on research in my lab (2001-2010) which provided fundamentally new insights into the physiological control of subcellular targeting. We computationally modeled large atomic-level protein/membrane systems and characterized the structural and energetic bases for the binding of proteins to membranes and for membrane-mediated processes in cells.  Validation of our models through close collaborations with experimental groups attest to the success of our research and it's impact on cell biology.  This approach is now being expanded to Cancer Systems Biology.