Dig Bijay Mahat

Dig Bijay Mahat

Titles

Assistant Professor, Department of Systems Biology

Principal Investigator, Laboratory of Immunogenomics at bi[o]hub

Affiliations
Department of Systems Biology
Email
dm4182@cumc.columbia.edu

Dig Bijay earned his B.S. in Biochemistry, Molecular Biology, and Bioinformatics from Towson University, completed his Ph.D. in Molecular Biology and Genetics at Cornell University with John Lis, and conducted postdoctoral training in Dr. Phillip Sharp’s laboratory at the Koch Institute for Integrative Cancer Research at MIT.

His lab investigates how non-coding DNA controls gene expression in health and disease. Focusing on enhancers that shape the tumor immune microenvironment in gastrointestinal cancers and those harboring genetic risk variants for autoimmune disorders, his group develops and applies single-cell transcriptomic assays, integrating them with AI and machine-learning frameworks to map gene-regulatory programs at high temporal resolution. Their goal is to identify and target disease-driving enhancers to advance new therapeutic strategies for immune dysfunction diseases.