Assistant Professor, Department of Systems Biology
Xuebing Wu is an assistant professor in the Department of Systems Biology and a member of the Cardiometabolic Genomics Program in the Cardiology Division in the Department of Medicine. Dr. Wu received his BS and MS in Control Science and Engineering from Tsinghua University, Beijing, with the highest honor. He then pursued his PhD in Computational and Systems Biology at Massachusetts Institute of Technology (MIT) as an HHMI International Student Research Fellow in the lab of Dr. Phillip Sharp. He completed his postdoctoral training in Dr. David Bartel’s lab at Whitehead Institute as a Helen Hay Whitney Fellow.
His research focuses on understanding the fundamental principles of gene regulation in human cells through integrative genomics approaches. His previous work has uncovered important roles of RNA sequence and structure signals in controlling the expression and evolution of the mammalian genome. His current lab studies RNA-centric gene regulation in mammalian systems, focusing on mRNA structures and mRNA translation. His lab also develops genomic technologies such as CRISPR/Cas and massively parallel reporter assays (MPRA) as well as novel computational tools to study genome regulation at global scale and nucleotide resolution. His lab seeks to bridge the discovery of basic mechanisms of gene regulation with the development of novel therapeutics for human diseases, focusing on cardiometabolic diseases.