Breakfast and Poster Setup

8:30 - 9:00

Opening Remarks

9:00 - 9:10
Andrea Califano and Barry Honig
Department update

9:10 - 9:20
Shannon Hughes
Cancer systems biology at the NCI

9:20 - 9:30
Peter Sims
The graduate program at the Department of Systems Biology

Session I

9:30 - 10:45

Andrea Califano
Elucidating and targeting the regulatory architecture of 10,000 tumors

Raul Rabadan
Spatiotemporal architecture of glioblastomas

Adolfo Ferrando
Genetics and mechanisms of relapsed acute lymphoblastic leukemia

Break

10:45 - 11:00

Session II

11:00 - 12:15

Barry Honig
Predicting protein–protein interactions with PrePPI: New features and applications

Saeed Tavazoie
Extreme cellular adaptation

Dennis Vitkup
Relative or absolute: environmental sensing in mammalian signaling pathways

Lunch and Posters

12:15 - 2:15

Session III

2:15 - 3:30

Cory Abate-Shen
Of mice and men: Using systems biology approaches to study human cancer

Tuuli Lappalainen
Haplotype epistasis with regulatory variants modifies penetrance of coding variants in human populations

Sagi Shapira
A germ-cell specific regulator of cytosolic nucleic acid sensing

Break

3:30 - 3:45

Session IV

3:45 - 5:00

Richard Mann
Scratching below the surface of transcription factor binding site prediction

Chaolin Zhang
Dynamic regulation of alternative splicing during neurodevelopment

Nicholas Tatonetti
Estimate of disease heritability using 4.7 million familial relationships inferred from electronic health records

Closing remarks and best poster award

5:00 - 5:05

Wine reception

5:05 - 6:00