Jiguang Wang

Overview

Jiguang Wang

Titles

Professor, The Hong Kong University of Science and Technology

Lab

Raul Rabadan

Jiguang Wang was a postdoctoral scientist in the Rabadan Lab. He worked on computational systems biology, specifically on the development of mathematical models to address medical and biological problems. His research revealed a novel type of non-coding RNA named xTSS-RNA, which plays an essential role in B-cell immunology and B-cell cancers. He is presently studying cancer evolution, aiming to reveal the evolutionary landscape of different cancers including glioblastoma multiforme, chronic lymphocytic leukemia, ependymona, and others.

Education History

PhD, Academy of Mathematics and Systems Science, Chinese Academy of Sciences
Operations Research and Bioinformatics

ScB, Beijing Institute of Technology, China
Mathematics

Publications

* indicates co-first authorship

Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. Elife. 2016 Jun 15;5. pii: e14709.

Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R. Clonal evolution of glioblastoma under therapy. Nat Genet. 2016 Jun 6. 

Sun J, Wang J, Pefanis E, Chao J, Rothschild G, Tachibana I, Chen JK, Ivanov II, Rabadan R, Takeda Y, Basu U. Transcriptomics identify CD9 as a marker of murine IL-10-competent regulatory B cells. 2015 Nov 10;13(6):1110-7.

Pefanis E*, Wang J*, Rothschild G*, Lim J*, Kazadi D, Sun J, Federation A, Chao J, Elliott O, Liu ZP, Economides AN, Bradner JE, Rabadan R, Basu U. RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity. Cell. 2015 May 7;161(4):774-89.

Wang J, Khiabanian H, Rossi D, Fabbri G, Gattei V, Forconi F, Laurenti L, Marasca R, Del Poeta G, Foà R, Pasqualucci L, Gaidano G, Rabadan R. Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia. Elife. 2014 Dec 11;3.

Pefanis E*, Wang J*, Rothschild G*, Lim J, Chao J, Rabadan R, Economides AN, Basu U. Noncoding RNA transcription targets AID to divergently transcribed loci in B cells. Nature. 2014 Oct 16;514(7522):389-93.

Wang J, Kribelbauer J, Rabadan R. Network propagation reveals novel genetic features predicting drug response of cancer cell lines. ISBRA 2014, LNBI 8492:386-386. Springer International Publishing, Switzerland.

Wang J. The research on molecular network models of complex disease. Sci Sin Math. 2014;44(4):317-328.

Wang J, Sun Y, Zheng S, Zhang XS, Zhou HR, Chen L. APG: an active protein-gene network model to quantify regulatory signals in complex biological systems. Sci Rep. 2013;3:1097. 

Wang J, Huang Q, Liu ZP, Wang Y, Wu LY, Chen L, Zhang XS. NOA: a novel network ontology analysis method. Nucleic Acids Res. 2011 Jul;39(13):e87.

Wang J, Zhang S, Wang Y, Chen L, Zhang XS. Disease-aging network reveals significant roles of aging genes in connecting genetic diseases. PLoS Comput Biol. 2009 Sep;5(9):e1000521.

Wang J, Qiu Y, Wang RS, Zhang XS. Remarks on network community properties. J Syst Sci Complexity 2008;21:637-644.

Song W*, Wang J*, Yang Y, Jing N, Zhang X, Chen L, Wu J. Rewiring drug-activated p53-regulatory network from suppressing to promoting tumorigenesis. J Mol Cell Biol. 2012 Aug;4(4):197-206.

Zhang C*, Wang J*, Hanspers K, Xu D, Chen L, Pico AR. NOA: a cytoscape plugin for network ontology analysis. Bioinformatics. 2013 Aug 15;29(16):2066-7.

Liu X*, Wang J*, Chen L. Whole-exome sequencing reveals recurrent somatic mutation networks in cancer. Cancer Lett. 2013 Nov 1;340(2):270-6.

Sun J, Keim CD, Wang J, Kazadi D, Oliver PM, Rabadan R, Basu U. E3-ubiquitin ligase Nedd4 determines the fate of AID-associated RNA polymerase II in B cells. Genes Dev. 2013 Aug 15;27(16):1821-33.

Rossi D, Khiabanian H, Spina V, Ciardullo C, Bruscaggin A, Famà R, Rasi S, Monti S, Deambrogi C, De Paoli L, Wang J, Gattei V, Guarini A, Foà R, Rabadan R, Gaidano G. Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. Blood. 2014 Apr 3;123(14):2139-47. 

Fabbri G, Khiabanian H, Holmes AB, Wang J, Messina M, Mullighan CG, Pasqualucci L, Rabadan R, Dalla-Favera R. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J Exp Med. 2013 Oct 21;210(11):2273-88. 

Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537-51.

Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, Guan Y, Zhao X, Yan J, Ni J, Nobrega MA, Löwenberg B, Delwel R, Valk PJ, Kumar A, Xie L, Tenen DG, Huang G, Wang QF. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 2013 Dec 26.

Zhang XS, Wang RS, Wang Y, Wang J, Qiu YQ, Wang L, Chen L. Modularity optimization in community detection of complex networks. Europhys Lett. 2009;87:38002.