Antonina Silkov is an associate research scientist in the Honig Lab. Her research is focused on structural mechanisms of cellular signaling; in particular, on finding the structural determinants of protein-membrane and protein-protein interactions.
Her activities include investigation of structural mechanisms of cancer progression such as analysis of the impact of mutations on protein-protein interactions, formation of macromolecular cancer-related complexes, and interaction of these complexes with cellular membranes. She also combines protein structural analysis with the statistical analysis of microarray data to get insight into competitive protein-protein interactions in cancer.
Before joining the Honig Lab, Antonina was an associate research scientist in Diana Murray's lab, where her research was focused on systematically analyzing the family of membrane-binding proteins
PhD, Weizmann Institute of Science
MSc, Simferopol State University, Ukraine
Sheng R, Jung DJ, Silkov A, Kim H, Singaram I, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Smrt S, Honig B, Beak K, Ryu S, Lorieau J, Kim YM, Cho W. Lipids regulate Lck activity through their interactions with the Lck SH2 domain. J Biol Chem. 2016 Jun 22.
Petrey D, Chen TS, Deng L, Garzon JI, Hwang H, Lasso G, Lee H, Silkov A, Honig B. Template-based prediction of protein function. Curr Opin Struct Biol. 2015 Feb 9;32C:33-38.
Kim DH, Park MJ, Gwon GH, Silkov A, Xu ZY, Yang EC, Song S, Song K, Kim Y, Yoon HS, Honig B, Cho W, Cho Y, Hwang I. An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids. Dev Cell. 2014 Sep 8;30(5):598-609.
Chen Y, Sheng R, Källberg M, Silkov A, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B, Lu H, Cho W. Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactions. Mol Cell. 2012 Apr 27;46(2):226-37.
Silkov A, Yoon Y, Lee H, Gokhale N, Adu-Gyamfi E, Stahelin RV, Cho W, Murray D. Genome-wide structural analysis reveals novel membrane binding properties of AP180 N-terminal homology (ANTH) domains. J Biol Chem. 2011 Sep 30;286(39):34155-63.
Lee H, Li Z, Silkov A, Fischer M, Petrey D, Honig B, Murray D. High-throughput computational structure-based characterization of protein families: START domains and implications for structural genomics. J Struct Funct Genomics. 2010 Mar;11(1):51-9.