Barry Honig

Barry Honig

Titles

Professor, Department of Systems Biology
Professor, Department of Biochemistry and Molecular Biophysics
Professor, Department of Medicine
Faculty, Zuckerman Institute
Faculty, Herbert Iving Comprehensive Cancer Center

 

 

Affiliations

Department of Systems Biology
Center for Computational Biology and Bioinformatics
Center for Cancer Systems Therapeutics
Department of Biochemistry and Molecular Biophysics
Department of Medical Sciences in Medicine
Zuckerman Institute
Herbert Irving Comprehensive Cancer Center

Phone

(212) 851-4651

Administrative Assistant:
Katie Rosa
212-851-4652
krr1@columbia.edu


Barry Honig has been a professor of Biochemistry and Molecular Biophysics at Columbia University College of Physicians and Surgeons since 1981 and is director of the Center for Computational Biology and Bioinformatics (C2B2). He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences, and was a Howard Hughes Medical Institute (HHMI) Investigator from 2000 - 2019. He is recipient of the Founders Award of the Biophysical Society, the Alexander Hollaender Award in Biophysics from National Academy of Sciences, Christian B. Anfinsen Award from the Protein Society, and DeLano Award for Computational Biosciences from the American Society for Biochemistry and Molecular Biology. He has also been named a Fellow of the American Association for the Advancement of Science, the Biophysical Society, and the International Society for Computational Biology.

The guiding hypothesis of Dr. Honig’s work is that combining information about protein sequence with biophysical analysis can reveal how biological specificity is encoded on protein structures. His laboratory uses methods from biophysics and bioinformatics to study the structure and function of proteins, nucleic acids, and membranes. His work includes fundamental theoretical research, the development of software tools, and applications to problems of biological importance.

More News

News

DSB Retreat Boasts Diverse Research, Spotlights Young Investigators
Each year the Department of Systems Biology community comes together for an off-campus retreat to discuss science, share ongoing research and to network. During this year's two-day program, held in Ellenville, NY, research presentations were primarily delivered by young investigators, shining a light on the ongoing work by our graduate students and post-docs.
Detailed Map Gives Scientists a New Window into how Human-Infecting Viruses Work
Columbia University biologists leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect. The method, along with the data that it generated, has spawned a wealth of information toward improving our understanding of how viruses manipulate the cells that they infect and cause disease. Among its findings, the work uncovered a role for estrogen receptor in regulating Zika Virus infection, as well as links between cancer and the human papillomavirus. The research, led by Dr. Sagi Shapira, appears Aug. 29 in the journal, Cell.
Spotlighting Interdisciplinary Research and Young Investigators
Innovative research projects were highlighted at the Department of Systems Biology’s annual retreat at Wave Hill Public Garden and Cultural Center. The retreat, attended by 160 guests, also provided an opportunity for young investigators to showcase their work during a poster competition. Congratulations goes out to this year's research poster winners: Andy Chiang (Vitkup Lab), Huijuan Feng (Zhang Lab) and Hanna Levitin (Sims Lab).
Symposium Spotlights Advancements in Translational Cancer Research
The recent Cancer Genomics Symposium featured talks by leading computational biologists, physicists, engineers, mathematicians, and oncologists, and explored important research grounded in cancer genomics and mathematical data analysis.
Database of Protein-Protein Interactions Opens New Possibilities for Systems Biology
PrePPI uses protein structural data to predict the likelihood that any two proteins interact. Its unprecedented scope is enabling the Honig Lab to ask new kinds of biological questions.