Daniel Scholes Rosenbloom

Overview

Daniel Scholes Rosenbloom

Titles

Postdoctoral Research Scientist

Email
dsr2131@columbia.edu

Website

My website

Lab

Raul Rabadan

I am a mathematical biologist in the Rabadan Lab at Columbia University Medical Center. I received my PhD in organismic and evolutionary biology at Harvard University with Martin Nowak, in the Program for Evolutionary Dynamics. I also collaborate with the Siliciano Lab at Johns Hopkins School of Medicine.

I am interested in theoretical biology and its applications to medical research. I use a mix of mathematical models and computational techniques to study a variety of biological systems. Specifically, I work on:

  • Dynamics of the HIV latent reservoir, emergence of drug resistance during treatment, and other aspects of viral evolution
  • Detecting patterns of horizontal evolution (recombination, reassortment) in viral and human populations
  • Epidemiology and the spread of health behaviors by imitation
  • Evolution of mutation rates ("second-order selection"), including how "rock-paper-scissors" competition can lead to hypermutation

For more information, see my website.

Education History

PhD, Harvard University
Organismic and Evolutionary Biology

AB, Harvard University
Mathematics, Philosophy

Publications

Camara PG, Rosenbloom DI, Emmett KJ, Levine AJ, Rabadan R. Topological data analysis generates high-resolution, genome-wide maps of human recombination. Cell Syst. 2016 Jul;3(1):83-94.

Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R. Clonal evolution of glioblastoma under therapy. Nat Genet. 2016 Jun 6.

Hill AL*, Rosenbloom DI*, Fu F, Nowak MA, Siliciano RF. Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1. Proc Nat Acad Sci USA. 2014. (in press)

Rosenbloom DI, Allen B. Frequency-dependent selection can lead to evolution of high mutation rates. Am Nat. 2014 May;183(5):E131-53.

Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DIS, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH. Rapid seeding of the viral reservoir prior to SIV viremia in rhesus monkeys. Nature. 2014. (in press) 

Ho Y-C, Shan L, Hosmane N, Wang J, Laskey SB, Rosenbloom DI, Lai J, Blankson JN, Siliciano JD, Siliciano RF. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell. 2013 Oct 24;155(3):540-51.

Rosenbloom DI*, Hill AL*, Rabi SA*, Siliciano RF, Nowak MA. Antiretroviral dynamics determines HIV evolution and predicts therapy outcome. Nat Med. 2012 Sep;18(9):1378-85.

Allen B, Rosenbloom DI. Mutation rate evolution in replicator dynamics. Bull Math Biol. 2012 Nov;74(11):2650-75.

Hill AL, Rosenbloom DI, Nowak MA. Evolutionary dynamics of HIV at multiple spatial and temporal scales. J Mol Med (Berl). 2012 May;90(5):543-61.

Fu F*, Rosenbloom DI*, Wang L, Nowak MA (2011). Imitation dynamics of vaccination behaviour on social networks. Proc Biol Sci. 2011 Jan 7;278(1702):42-9.

* indicates authors contributed equally