Erik Ladewig is pursuing a PhD in computational biology in Columbia's Integrated Program in Cellular, Molecular, Structural and Genetic Studies. His current interests include algorithms in statistical analysis of high-throughput data to infer disease mechanisms and evolution. Before attending Columbia he was a member of Eric Lai's laboratory at Memorial Sloan Kettering Cancer Center. While there, his research focused on biogenesis and post-transcriptional modifications of small non-coding regulatory RNAs.
Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R. Clonal evolution of glioblastoma under therapy. Nat Genet. 2016 Jun 6.
Gerstein MB, Rozowsky J, Yan KK, et al. Comparative analysis of the transcriptome across distant species. Nature. 2014 Aug 28;512(7515):445-8.
Wen J, Mohammed J, Bortolamiol-Becet D, Tsai H, Robine N, Westholm JO, Ladewig E, Dai Q, Okamura K, Flynt AS, Zhang D, Andrews J, Cherbas L, Kaufman TC, Cherbas P, Siepel A, Lai EC. Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines. Genome Res. 2014 Jul;24(7):1236-50.
Okamura K, Ladewig E, Zhou L, Lai EC. Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes Dev. 2013 Apr 1;27(7):778-92.
Ladewig E, Okamura K, Flynt AS, Westholm JO, Lai EC. Discovery of hundreds of mirtrons in mouse and human small RNA data. Genome Res. 2012 Sep;22(9):1634-45.
Westholm JO, Ladewig E, Okamura K, Robine N, Lai EC. Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs. RNA. 2012 Feb;18(2):177-92.