Gorka Lasso Cabrera

Overview

Gorka Lasso Cabrera

Titles

Associate Research Scientist

Email
gl2411@columbia.edu

Lab

Barry Honig

Gorka Lasso is an associate research scientist in the laboratory of Barry Honig and Sagi Shapira. His research focuses on the prediction of protein-protein interactions (PPIs) between viruses and their host. During his PhD at Swansea University, Wales, he developed of bioinformatics tools to annotate α-helical membrane proteins under the supervision of Jonathan Mullins. Following this, he moved to Mikel Valle’s lab at CICbioGUNE, Spain, as a postdoctoral research scientist. There, he combined cryo-electron microscopy and protein structure modeling in order to understand the intricate relationship between conformational variability and molecular function.

Education History

PhD, Swansea University                                                                                                               Bioinformatics

BS, University of Navarra                                                                                                               Biochemistry

Publications

Stockman VB, Ghamsari L, Lasso G, Honig B, Shapira SD, Wang HH. A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. PLoS One. 2016 Dec 9;11(12):e0167617.  

Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 6;538(7623):118-122.  

Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L. Structural basis of adhesive binding by desmocollins and desmogleins. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7160-5.  

Agirrezabala X, Méndez-López E, Lasso G, Sánchez-Pina MA, Aranda M, Valle M. The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses. Elife. 2015 Dec 16;4:e11795.  

Petrey D, Chen TS, Deng L, Garzon JI, Hwang H, Lasso G, Lee H, Silkov A, Honig B. Template-based prediction of protein function. Curr Opin Struct Biol. 2015 Jun;32:33-8.  

Lasso G, Yu LP, Gil D, Lázaro M, Tong L, Valle M. Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy. Structure. 2014 Jun 10;22(6):911-22.  

Julián P, Milon P, Agirrezabala X, Lasso G, Gil D, Rodnina MV, Valle M. The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. PLoS Biol. 2011 Jul;9(7):e1001095. 

Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Proc Natl Acad Sci U S A. 2011 Jan 11;108(Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):557-62.

Lasso G, Yu LP, Gil D, Xiang S, Tong L, Valle M. Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase. Structure. 2010 Oct 13;18(10):1300-10.  

Lasso G, Matthiesen R. Computational methods for analysis of two-dimensional gels. Methods Mol Biol. 2010;593:231-62. Book chapter.  

Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L. A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10;17(6):823-32.  

Hackenberg M, Lasso G, Matthiesen R. ContDist: a tool for the analysis of quantitative gene and promoter properties. BMC Bioinformatics. 2009 Jan 7;10:7.  

Lasso G, Antoniw JF, Mullins JG. A combinatorial pattern discovery approach for the prediction of membrane dipping (re-entrant) loops. Bioinformatics. 2006 Jul 15;22(14):e290-7.