Hang Song

Hang Song



(212) 851-4656

Hang Song is a postdoctoral research scientist in the laboratory of Barry Honig and Lawrence Shapiro. She studies the biophysics of cell adhesion, with a focus on the structure and dynamics of cadherin proteins, which mediate the formation of adhesive junctions at cell-cell contacts. Her long-term research interests lie in the development of multidisciplinary approaches to provide molecular explanations for cellular phenomena such as adhesion and signaling, with an emphasis on molecular recognition.

Prior to joining the Honig/Shapiro Lab, Hang was a graduate student in the research group of Jacqueline K. Barton at Caltech, where she was a recipient of the Tobacco-Related Disease Research Program (TRDRP) Dissertation Fellowship. In her graduate work she studied the recognition of nucleic acid mismatches by transition metal complexes.

Education History

PhD, California Institute of Technology

BA, Williams College
Chemistry, Economics


Vendome J*, Felsovalyi K*, Song H*, Yang Z, Jin X, Brasch J, Harrison OJ, Ahlsen G, Bahna F, Kaczynska A, Katsamba PS, Edmond D, Hubbell WL, Shapiro L, Honig B.   Structural and energetic determinants of adhesive binding specificity in type I cadherins. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4175-84. 
(*equal contributions)

McConnell AJ, Song H, Barton JK. Luminescence of [Ru(bpy)2(dppz)]2+ bound to RNA mismatches. Inorg Chem. 2013;52(17):10131-6.

Song H, Kaiser JT, Barton JK. Crystal structure of Delta-[Ru(bpy)2dppz]2+ bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation. Nat Chem. 2012;4(8):615-20.

McConnell AJ, Lim MH, Olmon ED, Song H, Dervan EE, Barton JK. Luminescent properties of ruthenium(II) complexes with sterically expansive ligands bound to DNA defects. Inorg Chem. 2012;51(22): 12511-20.

Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, van der Marel GA, Overkleeft HS, Aerts JM. Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010;53(2):689-98.

Lim MH, Song H, Olmon ED, Dervan EE, Barton JK. Sensitivity of Ru(bpy)2dppz2+ luminescence to DNA defects. Inorg Chem. 2009;48(12):5392-7.

Ernst RJ, Song H, Barton JK. DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors. J Am Chem Soc. 2009;131(6):2359-66.


Lab Staff