Hossein Khiabanian

Overview

Hossein Khiabanian

Titles

Assistant Professor, Rutgers Cancer Institute

Email
hk2524@columbia.edu

Lab

Raul Rabadan

Hossein Khiabanian is an Associate Research Scientist in the laboratory of Raul Rabadan and a member of the faculty in the Department of Biomedical Informatics at Columbia University. Hossein's current research is in quantitative biology—specifically, developing statistical methods to analyze genomic data, from the study of the molecular epidemiology of disease-causing organisms to investigating the genetics underlying human diseases. He has also worked on methods for the early detection of outbreaks, real-time disease surveillance, and analyzing electronic health records. Prior to joining Dr. Rabadan’s group, he was a member of the Observational Cosmology group at Brown University, where he received his PhD in physics.

Education History

ScM, PhD, Brown University
Physics

ScB, Sharif University of Technology, Tehran, Iran
Physics

Publications

Emmett KJ, Lee A, Khiabanian H, Rabadan R. High-resolution genomic surveillance of 2014 Ebolavirus using shared subclonal variants. PLoS Curr. 2015 Feb 9;7. pii: ecurrents.outbreaks.c7fd7946ba606c982668a96bcba43c90. 

Wang J, Khiabanian H, Rossi D, Fabbri G, Gattei V, Forconi F, Laurenti L, Marasca R, Del Poeta G, Foà R, Pasqualucci L, Gaidano G, Rabadan R. Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia. Elife. 2014 Dec 11;3.

Khiabanian H, Carpenter Z, Kugelman J, Chan J, Trifonov V, Nagle E, Warren T, Iversen P, Bavari S, Palacios G, Rabadan R. Viral diversity and clonal evolution from unphased genomic data. BMC Genomics. 2014 Oct 17;15(Suppl 6):S17. 

Lee A, Khiabanian H, Kugelman J, Elliott O, Nagle E, Yu GY, Warren T, Palacios G, Rabadan R. Transcriptome reconstruction and annotation of cynomolgus and African green monkey. BMC Genomics. 2014 Oct 3;15(1):846.

Pasqualucci L, Khiabanian H, Fangazio M, Vasishtha M, Messina M, Holmes AB, Ouillette P, Trifonov V, Rossi D, Tabbò F, Ponzoni M, Chadburn A, Murty VV, Bhagat G, Gaidano G, Inghirami G, Malek SN, Rabadan R, Dalla-Favera R. 2014.  Genetics of follicular lymphoma transformation. Cell Rep. 2014 Jan 16;6(1):130-40.

Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S. Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature. 2014 Feb 13;506(7487):240-4. 

Palomero T, Couronné L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R, Ferrando AA. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet. 2014 Feb;46(2):166-70. 

Rossi D, Khiabanian H, Spina V, Ciardullo C, Bruscaggin A, Famà R, Rasi S, Monti S, Deambrogi C, De Paoli L, Wang J, Gattei V, Guarini A, Foà R, Rabadan R, Gaidano G. Clinical impact of small TP53 mutated subclones in chronic lymphocytic leukemia. Blood. 2014 Apr 3;123(14):2139-47.

Messina M, Del Giudice I, Khiabanian H, Rossi D, Chiaretti S, Rasi S, Spina V, Holmes AB, Marinelli M, Fabbri G, Piciocchi A, Mauro FR, Guarini A, Gaidano G, Dalla-Favera R, Pasqualucci L, Rabadan R, Foà R. Genetic lesions associated with chronic lymphocytic leukemia chemo-refractoriness. Blood. 2014 Apr 10;123(15):2378-88. 

Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Brunak S, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, White KP, Rzhetsky A. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013 Sep 26;155(1):70-80. 

Fabbri G, Khiabanian H, Holmes A, Wang J, Messina M, Mullighan CG, Pasqualucci L, Rabadan R, Dalla-Favera R.  Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J Exp Med. 2013 Oct 21;210(11):2273-88.

Tzoneva G, Perez-Garcia A, Carpenter Z, Khiabanian H, Tosello V, Allegretta M, Paietta E, Racevskis J, Rowe JM, Tallman MS, Paganin M, Basso G, Hof J, Kirschner-Schwabe R, Palomero T, Rabadan R, Ferrando A. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med. 2013 Mar;19(3):368-71. 

Rossi D, Rasi S, Spina V, Bruscaggin A, Monti S, Ciardullo C, Deambrogi C, Khiabanian H, Serra R, Bertoni F, Forconi F, Laurenti L, Marasca R, Dal-Bo M, Rossi FM, Bulian P, Nomdedeu J, Del Poeta G, Gattei V, Pasqualucci L, Rabadan R, Foà R, Dalla-Favera R, Gaidano G. Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood. 2013 Feb 21;121(8):1403-12.

Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH, Bower M, Friedman R, Sartor RB, Rabadan R, Schwabe RF. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell. 2012 Apr 17;21(4):504-16. 

Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, Ma J, Grunn A, Fangazio M, Capello D, Monti S, Cresta S, Gargiulo E, Forconi F, Guarini A, Arcaini L, Paulli M, Laurenti L, Larocca LM, Marasca R, Gattei V, Oscier D, Bertoni F, Mullighan CG, Foá R, Pasqualucci L, Rabadan R, Dalla-Favera R, Gaidano G. Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med. 2011 Jul 4;208(7):1389-401.

Holmes A, Hawson A, Liu F, Friedman C, Khiabanian H, Rabadan R. Discovering disease associations by integrating electronic clinical data and medical literature. PLoS One. 2011;6(6):e21132. 

Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A. PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet. 2010 Apr;42(4):338-42. 

Khiabanian H, Holmes AB, Kelly BJ, Gururaj M, Hripcsak G, Rabadan R. Signs of the 2009 influenza pandemic in the New York-Presbyterian Hospital electronic health records. PLoS One. 2010 Sep 9;5(9). pii: e12658. 

Khiabanian H, Van Vlierberghe P, Palomero T, Ferrando AA, Rabadan R. ParMap, an algorithm for the identification of small genomic insertions and deletions in nextgen sequencing data. BMC Res Notes. 2010 May 27;3:147. 

Khiabanian H, Trifonov V, Rabadan R. Reassortment patterns in Swine influenza viruses. PLoS One. 2009 Oct 7;4(10):e7366.

Khiabanian H, Farrell GM, St George K, Rabadan R. Differences in patient age distribution between influenza A subtypes. PLoS One. 2009 Aug 31;4(8):e6832.

Trifonov V, Khiabanian H, Rabadan R. Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus. N Engl J Med. 2009 Jul 9;361(2):115-9.

Trifonov V, Khiabanian H, Greenbaum B, Rabadan R. The origin of the recent swine influenza A(H1N1) virus infecting humans. Euro Surveill. 2009 Apr 30;14(17). pii: 19193.