Karin Isaev

Karin Isaev


Graduate Research Assistant (DSB)

Karin is a PhD student in the Systems Biology department at Columbia University Medical Center. She completed her Bachelor and Master's of Science degrees at the University of Toronto where she studied non-coding RNA expression in cancer. At the Knowles lab, Karin is excited to apply machine learning methods to improve our understanding of complex RNA regulation processes and their dysregulation in disease. Outside of the lab, Karin is a member of Women in Science at Columbia (WISC) where she organizes a variety of workshops aimed at sharing computational skills. 

Education History
BSc, University of Toronto
Biochemistry and Nutritional Science
MSc, University of Toronto
Medical Biophysics

[1]  Helen Zhu*, Liis Uusku ̈la-Reimand*, Keren Isaev*, Lina Wadi, Azad Alizada, Shimin Shuai, Vincent Huang, Dike Aduluso-Nwaobasi, Marta Paczkowska, Diala Abd-Rabbo, et al. Candidate cancer driver mutations in distal regulatory elements and long-range chromatin interaction networks. Molecular cell, 77(6):1307–1321, 2020.
[2]  Keren Isaev*, Daisuke Ennishi, Laura Hilton, Brian Skinnider, Karen L Mungall, Andrew J Mungall, Mehran Bakthiari, Rosemarie Tremblay-LeMay, Anjali Silva, Susana Ben-Neriah, et al. Molecular attributes underlying central nervous system and systemic relapse in diffuse large B-cell lymphoma. Haematologica, 106(5):1466, 2021.
[3]  Keren Isaev*, Lingyan Jiang*, Shuai Wu*, Christian A Lee, Val ́erie Watters, Victoire Fort, Ricky Tsai, Fiona J Coutinho, Samer MI Hussein, Jie Zhang, et al. Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncrna HOXA10-AS in gliomas. Cell Reports, 37(3):109873, 2021.
[4]  Kit I Tong*, Sharon Yoon*, Keren Isaev*, Mehran Bakhtiari, Tracy Lackraj, Michael Y He, Jesse Joynt, Anjali Silva, Maria C Xu, Gilbert G Priv ́e, et al. Combined EZH2 inhibition and IKAROS degradation leads to enhanced antitumor activity in diffuse large B-cell lymphoma. Clinical Cancer Research, 27(19):5401–5414, 2021.
[5]  Keren Isaev*, Ting Liu, Mehran Bakhtiari, Kit Tong, Rashmi Goswami, Bernard Lam, Ilinca Lungu, Paul M. Krzyzanowski, Amit Oza, Neesha Dhani, Anca Prica, Michael Crump, and Robert Kridel. In-depth characterization of intratumoral heterogeneity in refractory B-cell non-hodgkin lymphoma through the lens of a research autopsy program. Haematologica, 2022.