I am a wet-lab postdoctoral research scientist working closely with dry lab scientists in the Zhang Lab. My research focuses on the splicing regulatory network of RNA binding proteins in the brain and in embryonic stem cell-derived motor neurons. I have worked on generating mouse cortex development transcriptome data, which has been used to uncover so-called "dark matter" in the mammalian transcriptome. I have participated in the establishment of the Rbfox regulatory network and am studying the function of Rbfox RNA-binding proteins in ES cell-derived neurons by making perturbations using the CRISPR/Cas9 genome-engineering technique.
Prior to joining Columbia University, I conducted research on transcription regulation and the evolution of the mammalian electrophysiological system in the lab of David McKinnon at Stony Brook University, where I received my PhD in neuroscience.
* indicates equal author contributions
Yan Q*, Weyn-Vanhentenryck SM*, Wu J, Sloan SA, Zhang Y, Chen K, Wu JQ, Barres BA, Zhang C. Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. Proc Natl Acad Sci U S A. 2015 Mar 3.
Weyn-Vanhentenryck S *, Mele A *, Yan Q *, Sun S, Farny N, Zhang Z, Xue C, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep. 2014 Mar 27;6(6):1139-52.
Yan Q, Masson R, Ren Y, Rosati B and McKinnon D. Evolution of CpG island promoter function underlies changes in KChIP2 potassium channel subunit gene expression in mammalian heart. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1601-6.
Rosati B, Yan Q, Lee MS, Liou SR, Ingalls B, Foell JD, Kamp TJ, McKinnon D. Robust L-type calcium current expression following heterozygous knockout of the Cav1.2 gene in adult mouse heart. J Physiol. 2011 Jul 1;589(Pt 13):3275-88.
Rosati B, Dong M, Cheng L, Liou SR, Yan Q, Park JY, Shiang E, Sanguinetti M, Wang HS, McKinnon D. Evolution of ventricular myocyte electrophysiology. Physiol Genomics. 2008 Nov 12;35(3):262-72.
Yan Q, Zhang N, Wu J, Zhang T. ERPDB: an integrated database of ERP data for neuroinformatics research. Data Sci J. 2007;6S743-S748.