Associate Professor, Department of Systems Biology
Chaolin Zhang uses a combination of computational and experimental methods to infer RNA regulatory networks in the nervous system. In particular, he is interested in characterizing the regulatory networks that specify neuronal cell types, and how how these networks can be compromised in certain pathologic contexts, such as brain tumors and neurodegenerative diseases.
After completing his PhD training at Cold Spring Harbor Laboratory and the Department of Biomedical Engineering at Stony Brook University, he was a member of Robert Darnell’s laboratory at the Rockefeller University, initially as a postdoctoral associate and later as a research assistant professor. While there, he studied neuron-specific RNA regulatory networks by developing an integrative modeling approach that combines multiple types of high-throughput data, including transcriptome profiles and protein-RNA interaction maps. He joined the Columbia Initiative in Systems Biology in 2012.